ERRα Antibody (2ERR2): sc-65718

ERRα Antibody (2ERR2) is a mouse monoclonal IgG2a kappa light chain antibody that detects ERRα protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). anti-ERRα antibody (2ERR2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Estrogen-related receptor alpha (ERRα) is a crucial nuclear receptor within the superfamily of ligand-regulated transcription factors, specifically classified as a member of the NR3B orphan nuclear receptor subgroup, which includes ERRα, ERRβ, and ERRγ. ERRα is primarily located in the nucleus, where ERRα plays a vital role in regulating gene expression related to energy metabolism and mitochondrial function. Nuclear localization of ERRα is significant because ERRα directly influences the transcription of genes involved in mitochondrial biogenesis and oxidative metabolism, processes that are essential for maintaining cellular energy homeostasis. ERRα expression increases during fasting and cold exposure, highlighting ERRα′s importance in adaptive responses to metabolic stress. Studies have indicated that ERRα may contribute to the maintenance and formation of cartilage, suggesting ERRα′s potential relevance in developing therapeutic strategies for joint-related diseases. Understanding the functional implications of ERRα′s nuclear activity can provide insights into ERRα′s role in various physiological and pathological processes, making ERRα (2ERR2) monoclonal antibody a valuable tool for researchers investigating these areas.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ERRα Antibody (2ERR2) References:

1. ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease.  |  Xia, H., et al. 2019. Front Endocrinol (Lausanne). 10: 206. PMID: 31024446
2. PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control.  |  Valcarcel-Jimenez, L., et al. 2019. Cancer Res. 79: 6153-6165. PMID: 31594836
3. A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis.  |  Chen, Y., et al. 2020. Theranostics. 10: 7193-7210. PMID: 32641987
4. miR-137/ERRα axis mediates chemoresistance of nasopharyngeal carcinoma cells.  |  Liu, F., et al. 2022. J Cell Commun Signal. 16: 103-113. PMID: 34196940
5. Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression.  |  Mao, X., et al. 2022. J Exp Clin Cancer Res. 41: 28. PMID: 35045880
6. Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis.  |  Xia, H., et al. 2022. Nat Commun. 13: 2105. PMID: 35440636
7. Advances in Medicinal Chemistry of Estrogen-related Receptor Alpha (ERRα) Inverse Agonists.  |  Zhang, H., et al. 2023. Curr Top Med Chem. 23: 1952-1963. PMID: 37190810
8. Dihydroartemisinin suppresses glioma growth by repressing ERRα-mediated mitochondrial biogenesis.  |  Zhang, W., et al. 2024. Mol Cell Biochem. 479: 2809-2825. PMID: 38072894
9. The PGC-1α/ERRα/ULK1 pathway contributes to Perioperative neurocognitive disorders by inducing mitochondrial dysfunction and activating NLRP3 inflammasome in aged mice.  |  Zhang, W., et al. 2024. Neuropharmacology. 260: 110119. PMID: 39197819
10. ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.  |  Sato, K., et al. 2024. Proc Natl Acad Sci U S A. 121: e2406854121. PMID: 39231208

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ERRα Antibody (2ERR2) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-ERRα Antibody (2ERR2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ERRα Antibody (2ERR2) Specifications

Alternate Product Name: Estrogen Related Receptor Alpha

Product Clone Name: 2ERR2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-78

Epitope Target: ERRα

Epitope Species: human

Product Reactivity/Detection: ERRα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for ERRα Antibody (2ERR2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred ERRα antibody is ERRα Antibody (2ERR7): sc-65720.