ERp5 Antibody (C-4): sc-374494

ERp5 Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects ERp5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERp5, also known as PDIA6 or TXNDC7, is a 440 amino acid protein characterized by two thioredoxin domains, which are crucial for its role in the endoplasmic reticulum. ERp5 is primarily localized to the lumen of the endoplasmic reticulum and the melanosome, where ERp5 plays a vital role in catalyzing the rearrangement of disulfide bonds in various proteins. ERp5′s ability to reduce disulfide bonds is particularly important as ERp5 facilitates the release of MICA from tumor cells, thereby inhibiting tumor expansion. Additionally, ERp5 undergoes alternative splicing, resulting in multiple isoforms that may have distinct functions or regulatory mechanisms. With a significant role in protein folding and cellular stress responses, ERp5 is a critical component in maintaining cellular homeostasis and has implications in cancer biology, making anti-ERp5 antibody (C-4) an essential tool for researchers studying these processes.

The preferred ERp5 antibody is ERp5 Antibody (G-5): sc-365260.