ERK 2 Antibody (6H3): sc-81459
- ERK 2 Antibody (6H3) is a mouse monoclonal IgG1, cited in 10 publications, provided at 50 µg/0.5 ml
- raised against the N-terminus of ERK 2 of human origin
- recommended for detection of ERK 2 of mouse, rat, human and canine origin by WB and IP
- See ERK 2 (D-2): sc-1647 for ERK 2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERK 2 Antibody (6H3). This work is in progress.
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ERK 2 Antibody (6H3) is a mouse monoclonal IgG1 antibody raised against the N-terminus of human ERK2 (Extracellular Signal-Regulated Kinase 2), also known as MAPK1 or p42 MAPK, a key serine/threonine kinase in the MAPK/ERK signaling pathway. Anti-ERK 2 antibody (6H3) is recommended for western blotting (WB) and immunoprecipitation (IP) assays across species, including mouse, rat, human, and canine samples. ERK2 plays a pivotal role in transmitting extracellular signals from cell surface receptors to the nucleus, regulating cellular processes such as proliferation, differentiation, migration, and survival. ERK2 undergoes critical post-translational modifications, specifically dual phosphorylation at threonine 183 and tyrosine 185 residues, which are essential for its activation. These phosphorylation events trigger conformational changes, enabling ERK2 to translocate to the nucleus and phosphorylate transcription factors such as Elk-1, which in turn regulate gene expression. Aberrant regulation of ERK2 phosphorylation can lead to uncontrolled cell growth and is implicated in various cancers, making the study of ERK2 activation crucial for cancer research. ERK 2 monoclonal antibody (6H3) is an invaluable resource for researchers investigating the MAPK/ERK pathway, cellular signaling mechanisms, protein-protein interactions, and the dynamic regulation of phosphorylation during signal transduction.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERK 2 Antibody (6H3) | sc-81459 | 50 µg/0.5 ml | $316.00 |