ERCC1 Antibody (A-2): sc-515258

ERCC1 Antibody (A-2) is a mouse monoclonal IgG2a antibody that detects ERCC1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERCC1 plays a crucial role in the DNA repair process, particularly in nucleotide excision repair, where ERCC1 forms a complex with the XPF protein, also known as ERCC4 or ERCC11. This complex is essential for the proper functioning of the structure-specific endonuclease that performs 5′ incisions during DNA repair, thereby facilitating the removal of damaged DNA segments. ERCC1′s importance lies in maintaining genomic stability and preventing mutations that could lead to conditions such as xeroderma pigmentosum, a disorder characterized by heightened sensitivity to UV radiation and an increased risk of skin cancer. By understanding ERCC1′s function and interactions within the DNA repair machinery, researchers can gain insights into the mechanisms of DNA damage response and potential therapeutic targets for enhancing DNA repair in various diseases. Anti-ERCC1 antibody (A-2) serves as an invaluable tool for studying these critical processes in human cells.

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ERCC1 Antibody (A-2) References:

1. ERCC1 expression and chemosensitivity in uterine cervical adenocarcinoma cells.  |  Torii, Y., et al. 2014. Anticancer Res. 34: 107-15. PMID: 24403450
2. ERCC1 siRNA ameliorates drug resistance to cisplatin in gastric carcinoma cell lines.  |  Li, W., et al. 2014. Mol Med Rep. 9: 2423-8. PMID: 24699918
3. Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage.  |  Liccardi, G., et al. 2014. Clin Cancer Res. 20: 3496-506. PMID: 24780295
4. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.  |  McNeil, EM., et al. 2015. DNA Repair (Amst). 31: 19-28. PMID: 25956741
5. ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures.  |  Li, S., et al. 2019. iScience. 16: 63-78. PMID: 31153042
6. Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.  |  Wang, J., et al. 2020. Nat Commun. 11: 786. PMID: 32034146
7. Expression and Clinical Significance of ERCC1 and XPF in Human Hepatocellular Carcinoma.  |  Liao, X., et al. 2020. Onco Targets Ther. 13: 1059-1072. PMID: 32099408
8. Diagnostic and Prognostic Potential of Biomarkers CYFRA 21.1, ERCC1, p53, FGFR3 and TATI in Bladder Cancers.  |  Matuszczak, M. and Salagierski, M. 2020. Int J Mol Sci. 21: PMID: 32397531
9. ERCC1 expression and platinum chemosensitivity in patients with ovarian cancer: A meta-analysis.  |  Zhang, C., et al. 2020. Int J Biol Markers. 35: 12-19. PMID: 33126828
10. Significance of ERCC1 and Hormonal Receptor Expression in Ovarian Cancer.  |  El-Moniem Elrawi, DA., et al. 2020. J Med Invest. 67: 391-398. PMID: 33148925

The preferred ERCC1 antibody is ERCC1 Antibody (D-10): sc-17809.