ErbB4/HER4 Antibody (2Q322): sc-71071

ErbB-4 Antibody (2Q322) is a mouse monoclonal IgG2b antibody that detects ErbB-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. ErbB-4 plays a crucial role in cell signaling pathways that regulate cell proliferation and differentiation, making ErbB-4 a significant player in various physiological processes and a potential target in cancer research. ErbB-4 is primarily located in the cell membrane, where ErbB-4 forms homodimers or heterodimers upon ligand binding, which is essential for activation and subsequent signaling cascades. ErbB-4 expression is notably high in breast carcinoma cell lines, as well as in normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum, highlighting ErbB-4′s importance in both normal physiology and disease states. The gene encoding ErbB-4 produces a full-length protein that undergoes proteolytic cleavage, resulting in a short membrane-anchored cytoplasmic domain fragment that exhibits tyrosine kinase activity, and a long ectodomain fragment. The binding of heregulin promotes this cleavage, further emphasizing the dynamic regulation of ErbB-4 activity and implications in cancer biology. Anti-ErbB-4 antibody (2Q322) is an invaluable tool for researchers investigating the role of this receptor in various biological contexts.

The preferred ErbB4/HER4 antibody is ErbB4/HER4 Antibody (C-7): sc-8050.