ERAP1 Antibody (731): sc-100727
- ERAP1 Antibody (731) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant ERAP1 of human origin
- recommended for detection of ERAP1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ERAP1 Antibody (731). This work is in progress.
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ERAP1 Antibody (731) is a mouse monoclonal IgG1 antibody that detects ERAP1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). ERAP1, or endoplasmic reticulum aminopeptidase 1, is crucially located in the lumen of the endoplasmic reticulum, where ERAP1 plays a vital role in processing antigenic precursors for MHC class I peptide presentation. ERAP1 is responsible for trimming peptides to the optimal length of eight to eleven amino acids, specifically targeting those that are nine amino acids or longer, which is essential for effective immune recognition. The precise regulation of peptide length by ERAP1 is important not only for immune response but also for maintaining the balance of bioactive peptides in the body, as ERAP1 can inactivate several peptides, including angiotensin II, thereby influencing blood pressure regulation. Additionally, ERAP1 is induced by interferon-γ and is encoded by the ARTS1 gene located on human chromosome 5q15, highlighting ERAP1′s significance in immune modulation and potential roles in angiogenesis through the regulation of endothelial cell behavior. With ERAP1′s ability to promote TNFR1 shedding, anti-ERAP1 antibody (731) serves as an invaluable tool for researchers studying immune responses and related pathways.
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ERAP1 Antibody (731) References:
- ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases. | Alvarez-Navarro, C. and López de Castro, JA. 2014. Mol Immunol. 57: 12-21. PMID: 23916068
- ERAP1 in the pathogenesis of ankylosing spondylitis. | Reeves, E., et al. 2014. Immunol Res. 60: 257-69. PMID: 25434650
- The role of polymorphic ERAP1 in autoinflammatory disease. | Reeves, E. and James, E. 2018. Biosci Rep. 38: PMID: 30054427
- The role of ERAP1 in autoinflammation and autoimmunity. | Pepelyayeva, Y. and Amalfitano, A. 2019. Hum Immunol. 80: 302-309. PMID: 30817945
- Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer. | Compagnone, M., et al. 2019. Hum Immunol. 80: 318-324. PMID: 30825518
- ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19? | D'Amico, S., et al. 2021. Int J Mol Sci. 22: PMID: 33567739
- ERAP1 as an emerging therapeutic target for medulloblastoma. | Bufalieri, F., et al. 2022. Trends Cancer. 8: 4-8. PMID: 34686465
- Down-regulation of ERAP1 mRNA expression in non-small cell lung cancer. | Wagner, M., et al. 2023. BMC Cancer. 23: 383. PMID: 37101107
- Shedding Light on the Role of ERAP1 in Axial Spondyloarthritis. | Saad, MA., et al. 2023. Cureus. 15: e48806. PMID: 38024089
- Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma. | Tempora, P., et al. 2024. J Exp Clin Cancer Res. 43: 292. PMID: 39438988
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERAP1 Antibody (731) | sc-100727 | 100 µg/ml | $333.00 |