epsin 4 Antibody (C-4): sc-518242
- epsin 4 Antibody (C-4) is a mouse monoclonal IgG1 provided at 200 µg/ml
- specific for an epitope mapping between amino acids 163-186 of epsin 4 of human origin
- recommended for detection of epsin 4 of human origin by WB, IP, IF and ELISA
- Anti-epsin 4 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for epsin 4 Antibody (C-4) for WB applications. These reagents are now offered in bundles with epsin 4 Antibody (C-4) (see ordering information below).
QUICK LINKS
epsin 4 Antibody (C-4) is a mouse monoclonal IgG1 antibody specific for an epitope mapping between amino acids 163-186 of epsin 4 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). epsin 4 monoclonal antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. epsin 4 plays a crucial role in the process of clathrin-mediated endocytosis, which is essential for the internalization of synaptic vesicles at presynaptic nerve terminals. This process is vital for neurotransmission and synaptic plasticity, as it regulates the recycling of synaptic vesicles and the availability of neurotransmitters. Disruption of epsin 4 function can lead to impaired endocytosis, which may contribute to neurological disorders, including schizophrenia, as abnormalities in epsin 4′s structure or expression have been linked to susceptibility to this condition. The epsin 4 gene is located on chromosome 5q33 and encodes a clathrin-associated protein that is integral to the transport and stability of neurotransmitter vesicles within neurons. anti-epsin 4 antibody (C-4) is recommended for researchers studying the mechanisms of synaptic function and the potential implications of epsin 4 in neuropsychiatric disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
epsin 4 Antibody (C-4) References:
- Curvature of clathrin-coated pits driven by epsin. | Ford, MG., et al. 2002. Nature. 419: 361-6. PMID: 12353027
- Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains. | Stahelin, RV., et al. 2003. J Biol Chem. 278: 28993-9. PMID: 12740367
- HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. | Hyun, TS., et al. 2004. J Biol Chem. 279: 14294-306. PMID: 14732715
- Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22. | Brzustowicz, LM., et al. 2004. Am J Hum Genet. 74: 1057-63. PMID: 15065015
- The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia. | Pimm, J., et al. 2005. Am J Hum Genet. 76: 902-7. PMID: 15793701
- Family-based association study of Epsin 4 and Schizophrenia. | Tang, RQ., et al. 2006. Mol Psychiatry. 11: 395-9. PMID: 16402136
- Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia. | Liou, YJ., et al. 2006. Schizophr Res. 84: 236-43. PMID: 16616458
- Membrane topology of helix 0 of the Epsin N-terminal homology domain. | Kweon, DH., et al. 2006. Mol Cells. 21: 428-35. PMID: 16819307
- Replication of genetic association studies between markers at the Epsin 4 gene locus and schizophrenia in two Han Chinese samples. | Gurling, H., et al. 2007. Schizophr Res. 89: 357-9. PMID: 17070672
- The epsin 4 gene is associated with psychotic disorders in families of Latin American origin. | Escamilla, M., et al. 2008. Schizophr Res. 106: 253-7. PMID: 18929466
- Association study of the GRIA1 and CLINT1 (Epsin 4) genes in a German schizophrenia sample. | Leon, CA., et al. 2011. Psychiatr Genet. 21: 114. PMID: 21116212
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
epsin 4 Antibody (C-4) | sc-518242 | 200 µg/ml | $322.00 | |||
epsin 4 Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-551587 | 200 µg Ab; 10 µg BP | $361.00 | |||
epsin 4 Antibody (C-4): m-IgG1 BP-HRP Bundle | sc-551586 | 200 µg Ab; 20 µg BP | $361.00 | |||
epsin 4 Antibody (C-4) AC | sc-518242 AC | 500 µg/ml, 25% agarose | $424.00 | |||
epsin 4 Antibody (C-4) HRP | sc-518242 HRP | 200 µg/ml | $322.00 | |||
epsin 4 Antibody (C-4) FITC | sc-518242 FITC | 200 µg/ml | $336.00 | |||
epsin 4 Antibody (C-4) PE | sc-518242 PE | 200 µg/ml | $349.00 | |||
epsin 4 Antibody (C-4) Alexa Fluor® 488 | sc-518242 AF488 | 200 µg/ml | $364.00 | |||
epsin 4 Antibody (C-4) Alexa Fluor® 546 | sc-518242 AF546 | 200 µg/ml | $364.00 | |||
epsin 4 Antibody (C-4) Alexa Fluor® 594 | sc-518242 AF594 | 200 µg/ml | $364.00 | |||
epsin 4 Antibody (C-4) Alexa Fluor® 647 | sc-518242 AF647 | 200 µg/ml | $364.00 | |||
epsin 4 Antibody (C-4) Alexa Fluor® 680 | sc-518242 AF680 | 200 µg/ml | $364.00 | |||
epsin 4 Antibody (C-4) Alexa Fluor® 790 | sc-518242 AF790 | 200 µg/ml | $364.00 |