Eps8L2 Antibody (WP.7): sc-100722
- Eps8L2 Antibody (WP.7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Eps8L2 of human origin
- recommended for detection of Eps8L2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Eps8L2 Antibody (WP.7). This work is in progress.
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Eps8L2 Antibody (WP.7) is a mouse monoclonal IgG1 antibody that detects Eps8L2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Eps8L2, also known as epidermal growth factor receptor kinase substrate 8-like protein 2, is a 715 amino acid protein that plays a crucial role in cellular signaling and cytoskeletal dynamics. Eps8L2 is primarily localized in the cytoplasm and is a member of the Eps8 family, which is involved in the regulation of actin cytoskeleton remodeling. Eps8L2 stimulates the guanine exchange activity of Sos 1, facilitating the exchange of GDP for GTP on Ras proteins, which is vital for the activation of downstream signaling pathways that govern cell growth and differentiation. Additionally, Eps8L2 interacts with actin, contributing to processes such as membrane ruffling, which is essential for cell motility and shape changes during various physiological events. Eps8L2 is expressed in tissues such as the placenta and fibroblasts and exists in two isoforms due to alternative splicing, featuring one phosphotyrosine interaction domain and one SH3 domain, which are important for functional interactions. Anti-Eps8L2 antibody (WP.7) is an invaluable tool for researchers studying the intricate roles of Eps8L2 in cellular processes and its implications in health and disease.
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Eps8L2 Antibody (WP.7) References:
- The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. | Offenhäuser, N., et al. 2004. Mol Biol Cell. 15: 91-8. PMID: 14565974
- Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. | Furness, DN., et al. 2013. Proc Natl Acad Sci U S A. 110: 13898-903. PMID: 23918390
- EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss. | Dahmani, M., et al. 2015. Orphanet J Rare Dis. 10: 96. PMID: 26282398
- Molecular Analysis of Twelve Pakistani Families with Nonsyndromic or Syndromic Hearing Loss. | Wang, R., et al. 2017. Genet Test Mol Biomarkers. 21: 316-321. PMID: 28281779
- Searching for prognostic biomarkers for small renal masses in the urinary proteome. | Di Meo, A., et al. 2020. Int J Cancer. 146: 2315-2325. PMID: 31465112
- Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content. | Zuo, X., et al. 2019. J Biol Chem. 294: 19099-19110. PMID: 31694916
- Re-examination of MAGE-A3 as a T-cell Therapeutic Target. | Martin, AD., et al. 2021. J Immunother. 44: 95-105. PMID: 33284140
- Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration. | Calero-Cuenca, FJ., et al. 2021. Curr Biol. 31: 1521-1530.e8. PMID: 33567288
- Predictive Biomarker Panel in Proliferative Lupus Nephritis- Two-Dimensional Shotgun Proteomics. | Ghasemi, M., et al. 2021. Iran J Kidney Dis. 1: 121-133. PMID: 33764323
- BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells. | Yan, K., et al. 2022. J Cell Physiol. 237: 774-788. PMID: 34346063
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eps8L2 Antibody (WP.7) | sc-100722 | 100 µg/ml | $339.00 |