ephrin-A1 Antibody (B-12): sc-377165
- ephrin-A1 Antibody (B-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 146-205 mapping at the C-terminus of ephrin-A1 of human origin
- recommended for detection of ephrin-A1 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ephrin-A1 Antibody (B-12) for WB applications. These reagents are now offered in bundles with ephrin-A1 Antibody (B-12) (see ordering information below).
ephrin-A1 Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects ephrin-A1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ephrin-A1, also known as LERK-1 or B61, plays a crucial role in cell signaling and communication, particularly in the development and function of the central nervous system. Anti-ephrin-A1 antibody (B-12) interacts with EphA2 (Eck) and EphA3 receptors, facilitating bidirectional signaling that influences cellular processes such as migration, adhesion, and differentiation. The importance of ephrin-A1 lies in its ability to regulate neuronal connections and synaptic plasticity, which are essential for learning and memory. Dysregulation of ephrin-A1 signaling has been implicated in various neurological disorders, making ephrin-A1 a significant target for research in neurobiology and therapeutic interventions. Anti-ephrin-A1 antibody (B-12) provides a valuable tool for studying these processes and understanding the underlying mechanisms of diseases associated with Eph receptor signaling.
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ephrin-A1 Antibody (B-12) References:
- ADAM12-cleaved ephrin-A1 contributes to lung metastasis. | Ieguchi, K., et al. 2014. Oncogene. 33: 2179-90. PMID: 23686306
- EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling. | Kaplan, N., et al. 2018. Invest Ophthalmol Vis Sci. 59: 393-406. PMID: 29351356
- Theoretical Model of EphA2-Ephrin A1 Inhibition. | Jedwabny, W., et al. 2018. Molecules. 23: PMID: 29997324
- Roles of EphA1/A2 and ephrin-A1 in cancer. | Ieguchi, K. and Maru, Y. 2019. Cancer Sci. 110: 841-848. PMID: 30657619
- Host deficiency in ephrin-A1 inhibits breast cancer metastasis. | Shiuan, E., et al. 2020. F1000Res. 9: 217. PMID: 32399207
- Plasma Ephrin-A1 level in a cohort of diabetic retinopathy patients. | Mao, D., et al. 2020. BMC Ophthalmol. 20: 319. PMID: 32758187
- Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions. | Ieguchi, K., et al. 2021. Int J Mol Sci. 22: PMID: 33804570
- Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19. | Mendoza, R., et al. 2021. Heliyon. 7: e07200. PMID: 34095559
- Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through Ephrin A1-EPHA2 forward signaling. | Han, B., et al. 2022. Theranostics. 12: 4127-4146. PMID: 35673569
- Ephrin A1 Stimulates CCL2 Secretion to Facilitate Premetastatic Niche Formation and Promote Gastric Cancer Liver Metastasis. | Cui, Y., et al. 2025. Cancer Res. 85: 263-276. PMID: 39412948
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ephrin-A1 Antibody (B-12) | sc-377165 | 200 µg/ml | $322.00 | |||
ephrin-A1 Antibody (B-12): m-IgG Fc BP-HRP Bundle | sc-540698 | 200 µg Ab; 10 µg BP | $361.00 | |||
ephrin-A1 Antibody (B-12): m-IgG1 BP-HRP Bundle | sc-542307 | 200 µg Ab; 20 µg BP | $361.00 |