EphB2 Antibody (SY4): sc-100298
- EphB2 Antibody (SY4) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant EphB2 of human origin
- recommended for detection of EphB2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EphB2 Antibody (SY4). This work is in progress.
EphB2 Antibody (SY4) is a mouse monoclonal IgG2a antibody that detects EphB2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). EphB2 is a member of the Eph receptor family, which represents the largest group of receptor protein tyrosine kinases identified to date, playing a crucial role in various biological processes, particularly in the central nervous system and during developmental stages. EphB2 is primarily located on the cell surface, where EphB2 interacts with ephrin-B ligands, facilitating bidirectional signaling that is essential for cell positioning, migration, and synaptic plasticity. This spatial regulation is vital for proper neuronal connectivity and function, highlighting the importance of EphB2 in neurodevelopmental processes and potential implications in neurological disorders. Anti-EphB2 antibody (SY4) is an invaluable tool for researchers investigating the dynamics of EphB2 signaling pathways and their contributions to cellular communication and development.
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EphB2 Antibody (SY4) References:
- RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. | Zhang, H., et al. 2021. Autophagy. 17: 3030-3047. PMID: 33280498
- EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma. | Leung, HW., et al. 2021. Cancer Res. 81: 3229-3240. PMID: 33903122
- The Roles of EphB2 in Cancer. | Liu, W., et al. 2022. Front Cell Dev Biol. 10: 788587. PMID: 35223830
- RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells. | Zhang, H., et al. 2022. J Immunol. 209: 1796-1805. PMID: 36130827
- Eph receptor B2 (EPHB2) regulates cancer stem cell-like properties in hepatocellular carcinoma. | Lim, JJ., et al. 2022. Stem Cell Investig. 9: 5. PMID: 36320882
- Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. | Xiao, Y., et al. 2023. Sci Transl Med. 15: eadc9653. PMID: 36753562
- EphB2-dependent prefrontal cortex activation promotes long-range social approach and partner responsiveness. | He, LN., et al. 2023. Proc Natl Acad Sci U S A. 120: e2219952120. PMID: 36802416
- EphB2 promotes enteric nitrergic hyperinnervation and neurogenic inflammation in DSS-induced chronic colitis in mice. | Chen, Y., et al. 2024. Int Immunopharmacol. 129: 111591. PMID: 38295544
- EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis. | Egal, ESA., et al. 2024. Arthritis Rheumatol. 76: 1303-1316. PMID: 38589317
- Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release. | Zhang, H., et al. 2024. Sci Adv. 10: eadi7024. PMID: 38758791
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EphB2 Antibody (SY4) | sc-100298 | 100 µg/ml | $339.00 |