EphB2 Antibody (48CT12.6.4): sc-130752
- EphB2 Antibody (48CT12.6.4) is a mouse monoclonal IgG1, cited in 5 publications, provided at 100 µg/ml
- raised against His-tagged purified recombinant EphB2 of human origin
- recommended for detection of EphB2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EphB2 Antibody (48CT12.6.4). This work is in progress.
EphB2 Antibody (48CT12.6.4) is a mouse monoclonal IgG1 antibody that detects EphB2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). EphB2 is a member of the Eph receptor family, which represents the largest group of receptor protein tyrosine kinases identified to date, playing a crucial role in mediating cell-cell interactions during development and in the central nervous system. EphB2 protein is primarily located on the cell surface, where EphB2 interacts with ephrin-B ligands, facilitating bidirectional signaling that is essential for processes such as neuronal development, synaptic plasticity, and angiogenesis. This localization allows EphB2 to participate in the regulation of cell migration and positioning, which are critical for proper tissue organization and function. Additionally, EphB2 has been implicated in various pathological conditions, including cancer, making EphB2 an important target for therapeutic interventions. With proven detection capabilities in multiple applications, anti-EphB2 antibody (48CT12.6.4) serves as a valuable tool for researchers studying cell signaling and development.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EphB2 Antibody (48CT12.6.4) References:
- RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. | Zhang, H., et al. 2021. Autophagy. 17: 3030-3047. PMID: 33280498
- EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma. | Leung, HW., et al. 2021. Cancer Res. 81: 3229-3240. PMID: 33903122
- The Value of EphB2 Receptor and Cognate Ephrin Ligands in Prognostic and Predictive Assessments of Human Breast Cancer. | Ebrahim, AS., et al. 2021. Int J Mol Sci. 22: PMID: 34360867
- RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells. | Zhang, H., et al. 2022. J Immunol. 209: 1796-1805. PMID: 36130827
- Eph receptor B2 (EPHB2) regulates cancer stem cell-like properties in hepatocellular carcinoma. | Lim, JJ., et al. 2022. Stem Cell Investig. 9: 5. PMID: 36320882
- Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. | Xiao, Y., et al. 2023. Sci Transl Med. 15: eadc9653. PMID: 36753562
- EphB2-dependent prefrontal cortex activation promotes long-range social approach and partner responsiveness. | He, LN., et al. 2023. Proc Natl Acad Sci U S A. 120: e2219952120. PMID: 36802416
- Interaction between the EPHB2 receptor and EFNB1 ligand drives gastric cancer invasion and metastasis via the Wnt/β-catenin/FAK pathway. | Hu, Y., et al. 2024. Int J Biol Macromol. 258: 128848. PMID: 38114003
- Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function. | Chang, C., et al. 2024. Elife. 12: PMID: 38289221
- Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release. | Zhang, H., et al. 2024. Sci Adv. 10: eadi7024. PMID: 38758791
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EphB2 Antibody (48CT12.6.4) | sc-130752 | 100 µg/ml | $322.00 |