EphB1/2/3 Antibody (EfB1-3): sc-135718

EphB1/2/3 (EfB1-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects EphB1/2/3 protein of mouse, rat, and chicken origin by western blotting (WB) and immunofluorescence (IF). Anti-EphB1/2/3 antibody (EfB1-3) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. EphB1/2/3 belongs to the Eph receptor family, representing the largest group of receptor protein tyrosine kinases identified to date. These receptors play a crucial role in various biological processes, including cell signaling, neuronal development, and tissue organization. EphB1/2/3 mediates interactions between cells and their environment, influencing processes such as cell migration and adhesion. Normal development and function of the central nervous system depend on proper EphB1/2/3 function, and dysregulation has been implicated in various diseases, including cancer and neurological disorders. EphB1/2/3 interacts with specific ligands, such as ephrin-A4 and ephrin-B2, which are essential for initiating signaling cascades that regulate cellular responses. Using EphB1/2/3 monoclonal antibody (EfB1-3) enables researchers to gain valuable insights into mechanisms underlying these critical biological functions and their implications in health and disease.

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EphB1/2/3 Antibody (EfB1-3) References:

1. EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System.  |  Kampen, KR., et al. 2015. Mol Cancer Res. 13: 982-92. PMID: 25944917
2. Ligand-independent EphB1 signaling mediates TGF-β-activated CDH2 and promotes lung cancer cell invasion and migration.  |  Wang, L., et al. 2020. J Cancer. 11: 4123-4131. PMID: 32368295
3. Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.  |  García-Ceca, J., et al. 2020. Dev Dyn. 249: 1243-1258. PMID: 32506584
4. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.  |  Zhang, H., et al. 2021. Autophagy. 17: 3030-3047. PMID: 33280498
5. EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma.  |  Leung, HW., et al. 2021. Cancer Res. 81: 3229-3240. PMID: 33903122
6. Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis.  |  Xiao, Y., et al. 2023. Sci Transl Med. 15: eadc9653. PMID: 36753562
7. EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.  |  Xie, Y., et al. 2024. Cancer Lett. 582: 216567. PMID: 38070822
8. EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis.  |  Egal, ESA., et al. 2024. Arthritis Rheumatol. 76: 1303-1316. PMID: 38589317
9. EphB1 causes retinal damage through inflammatory pathways in the retina and retinal Müller cells.  |  Liu, L., et al. 2024. Mol Vis. 30: 167-174. PMID: 38601015
10. Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.  |  Zhang, H., et al. 2024. Sci Adv. 10: eadi7024. PMID: 38758791

The preferred EphB1 antibody is EphB1 Antibody (5F10A4): sc-130054.