EphA7 Antibody (F-10): sc-393974

EphA7 Antibody (F-10) is a mouse monoclonal IgG2a antibody that detects EphA7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EphA7 is a member of the Eph receptor family, which plays a crucial role in the development of the nervous system by mediating axonal guidance. EphA7 is primarily located in the cell membrane, where EphA7 interacts with ephrins to facilitate repulsive signaling necessary for directing axonal growth cones to appropriate targets. Precise localization of EphA7 at the cell surface is vital for function, allowing immediate and localized responses to extracellular signals, ensuring developing neurons establish correct connections. Additionally, EphA7 undergoes various post-translational modifications, including phosphorylation, which can influence activity and interactions with other proteins. Anti-EphA7 antibody (F-10) is an essential tool for researchers studying neural development and mechanisms underlying axon guidance, providing insights into complex signaling pathways that govern these processes.

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EphA7 Antibody (F-10) References:

1. Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.  |  Rashid, T., et al. 2005. Neuron. 47: 57-69. PMID: 15996548
2. Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism.  |  Torii, M. and Levitt, P. 2005. Neuron. 48: 563-75. PMID: 16301174
3. Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients.  |  Wang, LF., et al. 2008. BMC Cancer. 8: 79. PMID: 18366728
4. EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells.  |  Johnson, C., et al. Cancer Genomics Proteomics. 13: 359-68. PMID: 27566654
5. Long noncoding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR-204/EphA7 axis.  |  Sun, Y., et al. 2020. J Cell Biochem. 121: 2962-2969. PMID: 31709597
6. MicroRNA-448/EPHA7 axis regulates cell proliferation, invasion and migration via regulation of PI3K/AKT signaling pathway and epithelial-to-mesenchymal transition in non-small cell lung cancer.  |  Liu, HY., et al. 2020. Eur Rev Med Pharmacol Sci. 24: 6139-6149. PMID: 32572879
7. EphA7+ perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model.  |  Kano, K., et al. 2020. Stem Cell Res. 47: 101914. PMID: 32738632
8. Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma-Associations with Clinical Parameters and Patient Survival.  |  Gajdzis, M., et al. 2020. Life (Basel). 10: PMID: 33007931
9. The Role of Biomarkers in the Early Diagnosis of Gastric Cancer: A Study on CCR5, CCL5, PDGF, and EphA7.  |  Bademler, S., et al. 2024. Curr Issues Mol Biol. 46: 10651-10661. PMID: 39329983
10. Altered TP53, CDKN2A, ATM, EPHA7, POT1, CHEK1, GRIN2A, and EGFR Predict Shorter Survival in Penile Squamous Cell Carcinoma.  |  Hojný, J., et al. 2024. Mod Pathol. 38: 100689. PMID: 39694330

The preferred EphA7 antibody is EphA7 Antibody (E-7): sc-393973.