EphA2 Antibody (C-3): sc-398832

EphA2 Antibody (C-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects EphA2 protein of mouse, rat, human, and mink origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-EphA2 antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EphA2, also known as Epithelial cell kinase, plays a crucial role in cell signaling and is involved in processes such as cell adhesion, migration, and differentiation, which are vital for normal development and tissue homeostasis. EphA2 is primarily located at the cell membrane, where EphA2 interacts with ephrin ligands to mediate bidirectional signaling that influences cellular responses. This membrane localization enables EphA2 to participate in regulating various physiological processes, including angiogenesis and neural development, and EphA2 dysregulation has been implicated in several diseases, including cancer. The Eph receptor family, which includes EphA2, represents the largest group of receptor protein tyrosine kinases identified to date, and understanding EphA2 function and interactions remains essential for elucidating roles in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

EphA2 Antibody (C-3) References:

1. EphA2 bears plasticity to tumor invasion.  |  Sugiyama, N., et al. 2013. Cell Cycle. 12: 2927-8. PMID: 23974090
2. Role of EphA2 in host defense against oro-pharyngeal candidiasis.  |  Olsen, I. 2020. J Oral Microbiol. 12: 1711619. PMID: 32002132
3. Development and preclinical characterization of a novel radiotheranostic EphA2-targeting bicyclic peptide.  |  El Fakiri, M., et al. 2024. Theranostics. 14: 4701-4712. PMID: 39239524
4. Ephrin receptor type-A2 (EphA2) targeting in cancer: a patent review (2018-present).  |  Tognolini, M., et al. 2024. Expert Opin Ther Pat. 34: 1009-1018. PMID: 39259047
5. EphA2 blockage ALW-II-41-27 alleviates atherosclerosis by remodeling gut microbiota to regulate bile acid metabolism.  |  Lu, C., et al. 2024. NPJ Biofilms Microbiomes. 10: 108. PMID: 39426981
6. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases.  |  Cheng, HJ. and Flanagan, JG. 1994. Cell. 79: 157-68. PMID: 7522971
7. Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.  |  Bennett, BD., et al. 1995. Proc Natl Acad Sci U S A. 92: 1866-70. PMID: 7534404
8. Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.  |  Valenzuela, DM., et al. 1995. Oncogene. 10: 1573-80. PMID: 7731712
9. Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system.  |  Ciossek, T., et al. 1995. Oncogene. 10: 97-108. PMID: 7824284
10. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.  |  Kozlosky, CJ., et al. 1995. Oncogene. 10: 299-306. PMID: 7838529
11. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.  |  Fox, GM., et al. 1995. Oncogene. 10: 897-905. PMID: 7898931
12. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.  |  Beckmann, MP., et al. 1994. EMBO J. 13: 3757-62. PMID: 8070404

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EphA2 Antibody (C-3) has 30 citations in a variety of scientific publications.

Primary antibodies like Anti-EphA2 Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EphA2 Antibody (C-3) Specifications

Alternate Product Name: EphA2

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 948-976

Epitope Target: EphA2

Epitope Species: mouse

Product Reactivity/Detection: EphA2

Species Reactivity/Detection: mouse, rat, human, mink

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 30 citations in various scientific publications

Available Conjugates/Forms for EphA2 Antibody (C-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin