EPDR1 Antibody (D-10): sc-393820

EPDR1 Antibody (D-10) is a mouse monoclonal IgG3 kappa light chain antibody that detects EPDR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-EPDR1 antibody (D-10) is available as the non-conjugated form. EPDR1, also known as ependymin-related protein 1, UCC1 (up-regulated in colorectal cancer gene 1 protein), MERP1, or MERP-1 (mammalian ependymin-related protein 1 precursor), is a 244 amino acid type II transmembrane protein belonging to the ependymin family. EPDR1 is predominantly expressed in various normal tissues, with the highest levels found in adult bone marrow and umbilical cord, indicating a potential role in developmental processes and tissue homeostasis. EPDR1 exhibits significant sequence similarity to ependymins, which are glycoproteins synthesized in fibroblasts and secreted into cerebrospinal fluid, suggesting a conserved function across species. EPDR1 features two glycosylation sites and a signal peptide, which are critical for proper localization and function, particularly in calcium-dependent cell adhesion processes. EPDR1 has two isoforms resulting from alternative splicing, which may contribute to functional diversity in cellular contexts.

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EPDR1 Antibody (D-10) References:

1. The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells.  |  Nimmrich, I., et al. 2001. Cancer Lett. 165: 71-9. PMID: 11248421
2. MERP1: a mammalian ependymin-related protein gene differentially expressed in hematopoietic cells.  |  Gregorio-King, CC., et al. 2002. Gene. 286: 249-57. PMID: 11943480
3. Gene expression profiles characterize early graft response in living donor small bowel transplantation: a case report.  |  Bradley, SP., et al. 2006. Transplant Proc. 38: 1742-3. PMID: 16908269
4. Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method.  |  Della Valle, MC., et al. 2006. J Biol Chem. 281: 35436-45. PMID: 16954209

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EPDR1 Antibody (D-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-EPDR1 Antibody (D-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EPDR1 Antibody (D-10) Specifications

Alternate Product Name: EPDR1

Product Clone Name: D-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 68-87

Epitope Target: EPDR1

Epitope Species: human

Product Reactivity/Detection: EPDR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for EPDR1 Antibody (D-10): P: Blocking Peptide