Endophilin II Antibody (H-2): sc-390013

Endophilin II Antibody (H-2) is a mouse monoclonal IgG1 antibody that detects endophilin II in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-endophilin II antibody (H-2) is a crucial tool for studying this member of the endophilin family, which plays a significant role in synaptic vesicle trafficking and membrane dynamics at nerve terminals. Endophilin II is primarily located in the brain, where endophilin II (H-2) monoclonal antibody helps reveal its involvement in the regulation of endocytosis and synaptic function, making endophilin II essential for neurotransmitter release and neuronal communication. Notably, endophilin II interacts with other key proteins such as amphiphysin and dynamin, which are vital for the formation and scission of vesicles during synaptic transmission. Proper functioning of endophilin II is critical for maintaining synaptic integrity and plasticity, and dysregulation of endophilin II activity has been linked to various neurological disorders. With specific reactivity and versatile applications, endophilin II (H-2) monoclonal antibody serves as an invaluable tool for researchers studying synaptic mechanisms and related pathologies.

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Endophilin II Antibody (H-2) References:

1. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.  |  Wu, J., et al. 2011. Cell. 147: 615-28. PMID: 22036569
2. miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma.  |  Shi, J., et al. 2013. Mol Med Rep. 8: 1111-7. PMID: 23970061
3. Distinct Functions of Endophilin Isoforms in Synaptic Vesicle Endocytosis.  |  Zhang, J., et al. 2015. Neural Plast. 2015: 371496. PMID: 26682072
4. SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway.  |  Guan, H., et al. 2016. Tumour Biol. 37: 12153-12160. PMID: 27220321
5. Essential role of SH3GL1 in interleukin-6(IL-6)- and vascular endothelial growth factor (VEGF)-triggered p130cas-mediated proliferation and migration of osteosarcoma cells.  |  Li, EQ. and Zhang, JL. 2017. Hum Cell. 30: 300-310. PMID: 28702842
6. Endophilin2 Interacts with GluA1 to Mediate AMPA Receptor Endocytosis Induced by Oligomeric Amyloid-β.  |  Zhang, J., et al. 2017. Neural Plast. 2017: 8197085. PMID: 28758034
7. Collapsin Response Mediator Protein 2 and Endophilin2 Coordinate Regulation of AMPA Receptor GluA1 Subunit Recycling.  |  Zhang, J., et al. 2020. Front Mol Neurosci. 13: 128. PMID: 32848595
8. MiR-3663-3p participates in the anti-hepatocellular carcinoma proliferation activity of baicalein by targeting SH3GL1 and negatively regulating EGFR/ERK/NF-κB signaling.  |  Tian, J., et al. 2021. Toxicol Appl Pharmacol. 420: 115522. PMID: 33838155
9. Endophilin-B regulates autophagy during synapse development and neurodegeneration.  |  Hernandez-Diaz, S., et al. 2022. Neurobiol Dis. 163: 105595. PMID: 34933093
10. The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.  |  Ringstad, N., et al. 1997. Proc Natl Acad Sci U S A. 94: 8569-74. PMID: 9238017

The preferred Endophilin II antibody is Endophilin II Antibody (A-11): sc-365704.