Endophilin B1 Antibody (A-9): sc-393191

Endophilin B1 Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects Endophilin B1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Endophilin B1 plays a crucial role in maintaining mitochondrial morphology and regulating the dynamics of the outer mitochondrial membrane, which is essential for cellular energy production and apoptosis regulation. The N-terminal domain of Endophilin B1 exhibits significant similarity to the lipid-binding and -modifying domain of class A Endophilins, highlighting involvement in lipid metabolism and membrane dynamics. Additionally, Endophilin B1′s interaction with other proteins, such as Amphiphysin and Dynamin, underscores importance in presynaptic vesicle trafficking at nerve terminals, a process vital for neurotransmitter release and synaptic plasticity. Expression of Endophilin B1 is particularly relevant in the context of neurodegenerative diseases, where alterations in mitochondrial function can lead to neuronal dysfunction. With specific reactivity and versatile applications, anti-Endophilin B1 antibody (A-9) serves as an invaluable tool for researchers investigating mitochondrial dynamics and synaptic function in human tissues.

The preferred Endophilin B1 antibody is Endophilin B1 Antibody (G-6): sc-374146.