ENC1 Antibody (7a): sc-517590

ENC1 Antibody (7a) is a mouse monoclonal IgG1 kappa light chain antibody that detects ENC1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-ENC1 antibody (7a) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. ENC1, also known as Ectoderm-neural cortex protein 1, plays a crucial role in the differentiation of neural crest cells and the regulation of neuronal process formation, making ENC1 vital for proper neural development. This 589 amino acid actin-binding protein is localized to the nuclear matrix and is highly expressed in adult brain and spinal cord tissues, with expression being up-regulated during neuronal differentiation. ENC1 regulation involves the β-catenin/TCF pathway, highlighting significance in histogenesis. ENC1 interacts with hypophosphorylated retinoblastoma-associated protein (Rb) to form a complex essential for neuronal cell differentiation, which includes components such as CUL-3 and Rbx1. Structurally, ENC1 contains one BTB (POZ) domain and six Kelch repeats; the BTB domain facilitates protein-protein interactions necessary for cytoskeletal organization, while the Kelch repeats indicate a conserved tertiary structure. ENC1 is highly expressed in brain tumors, suggesting a potential role in carcinogenesis, which underscores the importance of studying ENC1 in both developmental biology and cancer research.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ENC1 Antibody (7a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ENC1 Antibody (7a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ENC1 Antibody (7a) Specifications

Alternate Product Name: ENC1

Product Clone Name: 7a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 413-524

Epitope Target: ENC1

Epitope Species: mouse

Product Reactivity/Detection: ENC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ENC1 Antibody (7a): AC: Agarose, HRP: Horseradish Peroxidase

The preferred ENC1 antibody is ENC1 Antibody (SS-9): sc-100318.