Emx1 Antibody (G-6): sc-398115

Emx1 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Emx1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Emx1 antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Emx1 protein plays a crucial role in the development of the vertebrate brain, particularly in the formation of the dorsal telencephalon, where Emx1 is specifically expressed in pyramidal neurons. This expression pattern is vital for proper brain architecture and function, as Emx1 protein is involved in the regulation of neuronal differentiation and proliferation during embryonic development. Notably, Emx1 and its homolog Emx2 are part of a larger family of homeobox genes that are essential for establishing the anterior-posterior axis in the developing brain, with Emx1 being expressed later in the developmental timeline compared to Emx2. The genes encoding human Emx1 and Emx2 are located on chromosomes 2p14-p13 and 10q26.1, respectively, highlighting their evolutionary conservation and significance across species.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Emx1 Antibody (G-6) References:

1. Emx1 is a marker for pyramidal neurons of the cerebral cortex.  |  Chan, CH., et al. 2001. Cereb Cortex. 11: 1191-8. PMID: 11709490
2. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.  |  Gorski, JA., et al. 2002. J Neurosci. 22: 6309-14. PMID: 12151506
3. Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.  |  Simeone, A., et al. 1992. EMBO J. 11: 2541-50. PMID: 1352754
4. Nested expression domains of four homeobox genes in developing rostral brain.  |  Simeone, A., et al. 1992. Nature. 358: 687-90. PMID: 1353865
5. EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex.  |  Lim, JW., et al. 2015. Development. 142: 3746-57. PMID: 26534986
6. Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach.  |  Kobeissy, FH., et al. 2016. Front Mol Neurosci. 9: 98. PMID: 27799894
7. EMX1 functions as a tumor inhibitor in spinal cord glioma through transcriptional suppression of WASF2 and inactivation of the Wnt/β-catenin axis.  |  Han, Z., et al. 2022. Brain Behav. 12: e2684. PMID: 35849030
8. Emx1-Cre Is Expressed in Peripheral Autonomic Ganglia That Regulate Central Cardiorespiratory Functions.  |  Ning, Y., et al. 2022. eNeuro. 9: PMID: 36192157
9. DNA methylation-activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma.  |  Wen, DS., et al. 2023. Cell Death Dis. 14: 769. PMID: 38007497
10. Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1.  |  Ang, CE., et al. 2024. Proc Natl Acad Sci U S A. 121: e2308401121. PMID: 38446849
11. Chromosome locations of human EMX and OTX genes.  |  Kastury, K., et al. 1994. Genomics. 22: 41-5. PMID: 7959790
12. Emx1 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse.  |  Gulisano, M., et al. 1996. Eur J Neurosci. 8: 1037-50. PMID: 8743751

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Emx1 Antibody (G-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Emx1 Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Emx1 Antibody (G-6) Specifications

Alternate Product Name: Emx1

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-50

Epitope Target: Emx1

Epitope Species: human

Product Reactivity/Detection: Emx1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Emx1 Antibody (G-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent