Emt Antibody (0.T.74): sc-71040

Emt Antibody (0.T.74) is a mouse monoclonal IgG1 antibody that detects Emt in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and kinase assays. Emt, also known as Itk or Tsk, plays a crucial role in T cell signaling and activation, making Emt essential for the immune response. Emt protein is primarily located in the cytoplasm and regulates various cellular processes, including cell proliferation and differentiation. Emt presence in T cells helps modulate signaling pathways that lead to T cell activation, which is vital for an effective immune response against pathogens. Additionally, Emt interacts with CD28, a co-stimulatory molecule that enhances T cell activation upon ligation, thereby amplifying the immune response. Emt participation in these critical interactions underscores Emt significance in maintaining immune homeostasis and potential implications in immunological disorders. Anti-Emt antibody (0.T.74) serves as an invaluable tool for researchers studying T cell biology and the underlying mechanisms of immune regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Emt Antibody (0.T.74) References:

1. Genetic and immunologic features associated with scleroderma-like syndrome of TSK mice.  |  Saito, S., et al. 1999. Curr Rheumatol Rep. 1: 34-7. PMID: 11123012
2. Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.  |  Czar, MJ., et al. 2001. Biochem Soc Trans. 29: 863-7. PMID: 11709089
3. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.  |  Prince, AL., et al. 2009. Immunol Rev. 228: 115-31. PMID: 19290924
4. Regulation of T-cell responses and disease by tec kinase Itk.  |  August, A. and Ragin, MJ. 2012. Int Rev Immunol. 31: 155-65. PMID: 22449075
5. Interleukin-2-inducible T-cell kinase (ITK) deficiency - clinical and molecular aspects.  |  Ghosh, S., et al. 2014. J Clin Immunol. 34: 892-9. PMID: 25339095
6. Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.  |  Wang, X., et al. 2015. Front Immunol. 6: 117. PMID: 25821452
7. The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.  |  Huang, YC., et al. 2022. Int J Mol Sci. 23: PMID: 36012288
8. ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK.  |  Song, P., et al. 2022. Front Pharmacol. 13: 1071114. PMID: 36588692
9. ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas.  |  Jiang, B., et al. 2023. Cell Chem Biol. 30: 383-393.e6. PMID: 37015223
10. Combinatorial inhibition of Tec kinases BTK and ITK is beneficial in ameliorating murine sclerodermatous chronic graft versus host disease.  |  Palaniyandi, S., et al. 2023. Bone Marrow Transplant. 58: 924-935. PMID: 37160943

The preferred Emt antibody is Emt Antibody (2F12): sc-23902.