emerin Antibody (MANEM5): sc-81553
- emerin Antibody (MANEM5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against full length recombinant emerin of human origin
- recommended for detection of emerin of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for emerin Antibody (MANEM5) for WB applications. This reagent is now offered in a bundle with emerin Antibody (MANEM5) (see ordering information below).
QUICK LINKS
SEE ALSO...
Emerin Antibody (MANEM5) is a mouse monoclonal IgG1 antibody that detects emerin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-emerin antibody (MANEM5) recognizes a crucial component of the nuclear lamina, playing a significant role in maintaining the structural integrity of the nuclear envelope and facilitating chromatin organization. Emerin′s proper localization to the nuclear membrane is vital for cellular function, helping anchor the nuclear lamina to the inner nuclear membrane, thereby influencing gene expression and cellular signaling pathways. Mutations in the gene encoding emerin can lead to the X-linked recessive disorder Emery-Dreyfuss muscular dystrophy (EDMD), which manifests as progressive muscle weakness, contractures, and cardiac issues. Emerin′s association with desmosomes and fasciae adherentes in cardiac tissue is particularly noteworthy, as this relationship may contribute to the conduction defects observed in EDMD patients. Emerin monoclonal antibody (MANEM5) enables researchers to investigate emerin′s role in cellular processes and implications in muscular dystrophies, enhancing understanding of this critical protein′s function in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
emerin Antibody (MANEM5) References:
- Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes. | Holaska, JM., et al. 2006. Hum Mol Genet. 15: 3459-72. PMID: 17067998
- Emerin-prelamin A interplay in human fibroblasts. | Capanni, C., et al. 2009. Biol Cell. 101: 541-54. PMID: 19323649
- Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane. | Lee, B., et al. 2017. Biochim Biophys Acta Mol Cell Res. 1864: 303-313. PMID: 27865926
- Emerin Is Required for Proper Nucleus Reassembly after Mitosis: Implications for New Pathogenetic Mechanisms for Laminopathies Detected in EDMD1 Patients. | Dubińska-Magiera, M., et al. 2019. Cells. 8: PMID: 30871242
- Emerin knockdown induces the migration and invasion of hepatocellular carcinoma cells by up-regulating the cytoplasmic p21. | Wu, KY., et al. 2022. Neoplasma. 69: 59-70. PMID: 34734530
- Shared and Distinctive Neighborhoods of Emerin and Lamin B Receptor Revealed by Proximity Labeling and Quantitative Proteomics. | Cheng, LC., et al. 2022. J Proteome Res. 21: 2197-2210. PMID: 35972904
- Atrioventricular block in dilated cardiomyopathy and mutation in emerin gene. | Báez-Ferrer, N., et al. 2023. Med Clin (Barc). 161: 551-552. PMID: 37596164
- Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery-Dreifuss muscular dystrophy caused by an LMNA gene mutation. | Wada, E., et al. 2023. J Physiol Sci. 73: 27. PMID: 37940872
- Emerin deficiency drives MCF7 cells to an invasive phenotype. | Hansen, E., et al. 2024. Sci Rep. 14: 19998. PMID: 39198511
- Emerin preserves stem cell survival through maintenance of centrosome and nuclear lamina structure. | Jones, SD., et al. 2024. Development. 151: PMID: 39465887
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
emerin Antibody (MANEM5) | sc-81553 | 200 µg/ml | $322.00 | |||
emerin Antibody (MANEM5): m-IgG Fc BP-HRP Bundle | sc-539624 | 200 µg Ab; 10 µg BP | $361.00 |