EMBP Antibody (F-2): sc-365702
- EMBP Antibody (F-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-222 representing full length EMBP of human origin
- recommended for detection of EMBP of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for EMBP Antibody (F-2) for WB and IHC(P) applications. These reagents are now offered in bundles with EMBP Antibody (F-2) (see ordering information below).
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EMBP Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects eosinophil major basic protein (EMBP) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). EMBP is a critical component of the crystalline core of eosinophil granules, playing a significant role in the immune response, particularly in antiparasitic defense mechanisms. EMBP (F-2) antibody helps researchers study cytotoxic properties and involvement in immune hypersensitivity reactions, making anti-EMBP antibody (F-2) essential for understanding allergic responses and parasitic infections. EMBP is predominantly found in the placenta and pregnancy serum, where EMBP forms complexes with other proteins such as pregnancy-associated plasma protein A, angiotensinogen, and C3dg, highlighting EMBP′s importance in pregnancy-related immune modulation. Furthermore, EMBP′s transcription is regulated by intricate interactions among transcription factors like GATA-1, PU.1, and C/EBPε isoforms, which underscores EMBP′s complex regulatory mechanisms and potential implications in various physiological and pathological processes. Anti-EMBP antibody (F-2) serves as an invaluable tool for researchers aiming to explore the multifaceted roles of EMBP in human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EMBP Antibody (F-2) References:
- Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2. | Macias, MP., et al. 2000. J Leukoc Biol. 67: 567-76. PMID: 10770291
- Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. | Overgaard, MT., et al. 2003. J Biol Chem. 278: 2106-17. PMID: 12421832
- Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway. | Shenoy, NG., et al. 2003. J Immunol. 171: 3734-41. PMID: 14500673
- Association of immunoreactive eosinophil major basic protein with placental septa and cysts. | Wasmoen, TL., et al. 1991. Am J Obstet Gynecol. 165: 416-20. PMID: 1872350
- Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates. | Gundel, RH., et al. 1991. J Clin Invest. 87: 1470-3. PMID: 2010556
- Localization of eosinophil major basic protein onto eggs of Schistosoma mansoni in human pathologic tissue. | Kephart, GM., et al. 1988. Am J Pathol. 133: 389-96. PMID: 2461091
- Cough responses to inhaled irritants are enhanced by eosinophil major basic protein in awake mice. | Lin, AH., et al. 2019. Am J Physiol Regul Integr Comp Physiol. 317: R93-R97. PMID: 30995073
- Increases of plasma eosinophil major basic protein levels late in pregnancy predict onset of labor. | Wasmoen, TL., et al. 1987. Proc Natl Acad Sci U S A. 84: 3029-32. PMID: 3472249
- In situ crystalline structure of the human eosinophil major basic protein-1. | Yang, JE., et al. 2024. bioRxiv.. PMID: 39416224
- Binding of the wheat basic leucine zipper protein EmBP-1 to nucleosomal binding sites is modulated by nucleosome positioning. | Niu, X., et al. 1996. Plant Cell. 8: 1569-87. PMID: 8837510
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EMBP Antibody (F-2) | sc-365702 | 200 µg/ml | $322.00 | |||
EMBP Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-537825 | 200 µg Ab; 10 µg BP | $361.00 | |||
EMBP Antibody (F-2): m-IgGκ BP-HRP Bundle | sc-535240 | 200 µg Ab; 40 µg BP | $361.00 | |||
EMBP Antibody (F-2): m-IgG1 BP-HRP Bundle | sc-545380 | 200 µg Ab; 20 µg BP | $361.00 |