Elongin C Antibody (56): sc-135895

Elongin C Antibody (56) is a mouse monoclonal IgG1 antibody that detects Elongin C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Elongin C antibody (56) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical protein. Elongin C plays a vital role in the Elongin (SIII) complex, which is essential for regulating transcriptional elongation in eukaryotic cells. This complex is composed of three subunits: Elongin A, which is transcriptionally active, and the regulatory subunits Elongin B and Elongin C. The interaction of the von Hippel-Lindau (VHL) protein with Elongin B and C is particularly significant, as VHL modulates the transcriptional activity of the Elongin (SIII) complex, thereby influencing gene expression and cellular responses. Mutations in the VHL gene can lead to a range of tumors, highlighting the importance of understanding Elongin C function and regulation in cancer biology. Elongin C (56) monoclonal antibody enables researchers to gain insights into the molecular mechanisms underlying these processes and explore potential therapeutic targets.

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Elongin C Antibody (56) References:

1. Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy technique.  |  Kinoshita, K., et al. 2007. FEBS J. 274: 5567-75. PMID: 17922844
2. Elongin C is a mediator of Notch4 activity in human renal tubule cells.  |  Cummins, TD., et al. 2011. Biochim Biophys Acta. 1814: 1748-57. PMID: 22001063
3. Elongin C Contributes to RNA Polymerase II Degradation by the Interferon Antagonist NSs of La Crosse Orthobunyavirus.  |  Schoen, A., et al. 2020. J Virol. 94: PMID: 31941775
4. Elongin C (ELOC/TCEB1)-associated von Hippel-Lindau disease.  |  Andreou, A., et al. 2022. Hum Mol Genet. 31: 2728-2737. PMID: 35323939
5. Tumor suppression and transcription elongation: the dire consequences of changing partners.  |  Krumm, A. and Groudine, M. 1995. Science. 269: 1400-1. PMID: 7660121
6. Inhibition of transcription elongation by the VHL tumor suppressor protein.  |  Duan, DR., et al. 1995. Science. 269: 1402-6. PMID: 7660122
7. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.  |  Aso, T., et al. 1995. Science. 269: 1439-43. PMID: 7660129
8. Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII.  |  Garrett, KP., et al. 1994. Proc Natl Acad Sci U S A. 91: 5237-41. PMID: 8202474
9. Familial pheochromocytoma associated with a novel mutation in the von Hippel-Lindau gene.  |  Gross, DJ., et al. 1996. J Clin Endocrinol Metab. 81: 147-9. PMID: 8550742
10. Frequent allelic loss at chromosome arm 3p is distinct from genetic alterations of the Von-Hippel Lindau tumor suppressor gene in head and neck cancer.  |  Waber, PG., et al. 1996. Oncogene. 12: 365-9. PMID: 8570213
11. Characterization of elongin C functional domains required for interaction with elongin B and activation of elongin A.  |  Takagi, Y., et al. 1996. J Biol Chem. 271: 25562-8. PMID: 8810329
12. Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein.  |  Takagi, Y., et al. 1997. J Biol Chem. 272: 27444-9. PMID: 9341197

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Elongin C Antibody (56) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Elongin C Antibody (56) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Elongin C Antibody (56) Specifications

Alternate Product Name: Elongin C

Product Clone Name: 56

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1-112

Epitope Target: Elongin C

Epitope Species: human

Product Reactivity/Detection: Elongin C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Elongin C Antibody (56): N/A