Elongin A Antibody (F-11): sc-373812

Elongin A Antibody (F-11) is a mouse monoclonal IgG2a antibody that detects Elongin A in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Elongin A is a crucial component of the Elongin (SIII) complex, which plays a significant role in regulating transcriptional elongation and is essential for proper gene expression. The structure of Elongin A, which consists of a central coiled-coil domain flanked by two distinct regions, is vital for interaction with regulatory subunits Elongin B and Elongin C, forming a stable heterotrimer. This structural arrangement facilitates VHL protein recruitment and enhances the complex′s ability to modulate transcriptional activity, thereby influencing cellular responses to various stimuli. Understanding Elongin A structure and function is important, as dysregulation can lead to aberrant transcriptional control and contribute to tumorigenesis, particularly in VHL-related cancers. Anti-Elongin A antibody (F-11) is therefore an invaluable tool for researchers investigating the molecular mechanisms underlying these processes.

The preferred Elongin A antibody is Elongin A Antibody (A-5): sc-373811.