ELMSAN1 Antibody (B-10): sc-514710
- ELMSAN1 Antibody (B-10) is a mouse monoclonal IgG1 κ ELMSAN1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 631-657 within an internal region of ELMSAN1 of human origin
- ELMSAN1 Antibody (B-10) is recommended for detection of ELMSAN1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ELMSAN1 Antibody (B-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ELMSAN1 Antibody (B-10) for WB applications. These reagents are now offered in bundles with ELMSAN1 Antibody (B-10) (see ordering information below).
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ELMSAN1 Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ELMSAN1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ELMSAN1 (B-10) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ELMSAN1, also known as ELM2 and SANT domain-containing protein 1, LSR68, MIDEAS, or C14orf43, is a crucial 1,045 amino acid nuclear protein featuring one ELM2 domain and a SANT domain, playing a significant role in gene expression regulation. ELMSAN1 forms part of a deacetylase complex including transcriptional regulators such as TdTIF1 and histone deacetylase 1 (HDAC1), essential for maintaining chromatin structure and function. ELMSAN1 is encoded on human chromosome 14q24.2, a region associated with several genetic conditions, including Alzheimer′s disease due to proximity to presenilin 1 (PSEN1) gene. Additionally, chromosome 14 harbors SERPINA1 gene, whose mutations can lead to α1-anti-trypsin deficiency, causing severe lung and liver complications. The immunoglobulin heavy chain locus on chromosome 14, implicated in various B cell malignancies through translocations with chromosome 19 encoded proteins like Bcl-3, further underscores ELMSAN1′s importance in cellular processes and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ELMSAN1 Antibody (B-10) References:
- A presenilin 1 R278I mutation presenting with language impairment. | Godbolt, AK., et al. 2004. Neurology. 63: 1702-4. PMID: 15534260
- Pathological and physiological functions of presenilins. | Vetrivel, KS., et al. 2006. Mol Neurodegener. 1: 4. PMID: 16930451
- Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population. | Albani, D., et al. 2007. Neurobiol Aging. 28: 1682-8. PMID: 16952411
- Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies. | Micci, F., et al. 2007. Virchows Arch. 450: 559-65. PMID: 17406891
- A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. | Martín-Subero, JI., et al. 2007. Leukemia. 21: 1532-44. PMID: 17495977
- The genetics of very early onset Alzheimer disease. | Filley, CM., et al. 2007. Cogn Behav Neurol. 20: 149-56. PMID: 17846513
- The promise of gene therapy for the treatment of alpha-1 antitrypsin deficiency. | Cruz, PE., et al. 2007. Pharmacogenomics. 8: 1191-8. PMID: 17924834
- Alpha1-antitrypsin deficiency: current perspective on research, diagnosis, and management. | Stolk, J., et al. 2006. Int J Chron Obstruct Pulmon Dis. 1: 151-60. PMID: 18046892
- Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting. | Itoh, T., et al. 2015. Nucleic Acids Res. 43: 2033-44. PMID: 25653165
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ELMSAN1 Antibody (B-10) | sc-514710 | 200 µg/ml | $316.00 | |||
ELMSAN1 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-531200 | 200 µg Ab; 10 µg BP | $354.00 | |||
ELMSAN1 Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-524821 | 200 µg Ab, 40 µg BP | $354.00 | |||
ELMSAN1 Antibody (B-10): m-IgG1 BP-HRP Bundle | sc-544432 | 200 µg Ab; 20 µg BP | $354.00 | |||
ELMSAN1 Antibody (B-10) AC | sc-514710 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ELMSAN1 Antibody (B-10) HRP | sc-514710 HRP | 200 µg/ml | $316.00 | |||
ELMSAN1 Antibody (B-10) FITC | sc-514710 FITC | 200 µg/ml | $330.00 | |||
ELMSAN1 Antibody (B-10) PE | sc-514710 PE | 200 µg/ml | $343.00 | |||
ELMSAN1 Antibody (B-10) Alexa Fluor® 488 | sc-514710 AF488 | 200 µg/ml | $357.00 | |||
ELMSAN1 Antibody (B-10) Alexa Fluor® 546 | sc-514710 AF546 | 200 µg/ml | $357.00 | |||
ELMSAN1 Antibody (B-10) Alexa Fluor® 594 | sc-514710 AF594 | 200 µg/ml | $357.00 | |||
ELMSAN1 Antibody (B-10) Alexa Fluor® 647 | sc-514710 AF647 | 200 µg/ml | $357.00 | |||
ELMSAN1 Antibody (B-10) Alexa Fluor® 680 | sc-514710 AF680 | 200 µg/ml | $357.00 | |||
ELMSAN1 Antibody (B-10) Alexa Fluor® 790 | sc-514710 AF790 | 200 µg/ml | $357.00 | |||
ELMSAN1 (B-10) Neutralizing Peptide | sc-514710 P | 100 µg/0.5 ml | $68.00 |