Elmo1 Antibody (C-3): sc-166661
- Elmo1 Antibody (C-3) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length Elmo1 of mouse origin
- recommended for detection of Elmo1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Elmo1 Antibody (C-3) for WB applications. This reagent is now offered in a bundle with Elmo1 Antibody (C-3) (see ordering information below).
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Elmo1 Antibody (C-3) is a mouse monoclonal IgG2b antibody that detects Elmo1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Elmo1 plays a crucial role in the regulation of cytoskeletal dynamics, particularly during phagocytosis and cell motility, by interacting with other key proteins such as DOCK 180 and Crk. This interaction activates Rac1, a small GTPase that orchestrates actin cytoskeleton rearrangements necessary for cell spreading and migration. Elmo1′s importance in these pathways is highlighted by involvement in the engulfment of apoptotic cells, a process essential for maintaining tissue homeostasis and immune response. Furthermore, Src family kinase-mediated tyrosine phosphorylation of Elmo1 enhances signaling capabilities, thereby influencing various cellular functions. anti-Elmo1 antibody (C-3) serves as an invaluable tool for researchers studying the intricate mechanisms of cell motility and phagocytosis, providing insights into the molecular underpinnings of these critical biological processes.
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Elmo1 Antibody (C-3) References:
- ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. | Sharma, KR., et al. 2016. Sci Rep. 6: 37172. PMID: 27849017
- ELMO1 deficiency enhances platelet function. | Patel, A., et al. 2019. Blood Adv. 3: 575-587. PMID: 30787021
- ELMO1 signaling is a promoter of osteoclast function and bone loss. | Arandjelovic, S., et al. 2021. Nat Commun. 12: 4974. PMID: 34404802
- TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis. | Xie, Z., et al. 2021. Nat Commun. 12: 5373. PMID: 34508078
- Role of ELMO1 in inflammation and cancer-clinical implications. | Tocci, S., et al. 2022. Cell Oncol (Dordr). 45: 505-525. PMID: 35668246
- Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer. | Park, YL., et al. 2022. Anticancer Res. 42: 5343-5355. PMID: 36288887
- ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis. | Yu, S., et al. 2023. Int J Mol Sci. 24: PMID: 37175809
- Overexpression of Dock180 and Elmo1 in Melanoma is Associated with Cell Survival and Migration. | Lee, YJ., et al. 2023. Ann Dermatol. 35: 439-450. PMID: 38086358
- Acetylation of ELMO1 correlates with Rac1 activity and colorectal cancer progress. | Li, C., et al. 2024. Exp Cell Res. 439: 114068. PMID: 38750717
- ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis. | Chen, J., et al. 2024. Gastroenterol Rep (Oxf). 12: goae045. PMID: 38756351
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elmo1 Antibody (C-3) | sc-166661 | 200 µg/ml | $322.00 | |||
Elmo1 Antibody (C-3): m-IgG2b BP-HRP Bundle | sc-548527 | 200 µg Ab; 10 µg BP | $361.00 |