Elf-5 Antibody (G-2): sc-166653
- Elf-5 Antibody (G-2) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 238-255 at the C-terminus of Elf-5 of human origin
- recommended for detection of Elf-5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine; may cross-react with EHF, ESX, ESE-3a and ESE-3b
- TransCruz reagent for ChIP application (sc-166653 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Elf-5 Antibody (G-2). This work is in progress.
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Elf-5 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects Elf-5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Elf-5 is a crucial member of the Ets family of transcription factors, which bind to specific DNA sequences and regulate gene expression. Elf-5 plays a significant role in various biological processes, including lung, mammary, prostate, and kidney development, as well as in the regulation of cell differentiation and proliferation. Elf-5′s involvement in tumorigenesis may influence the progression of certain cancers. Elf-5′s structure features a highly conserved carboxy-terminal domain essential for DNA-binding activity, allowing interaction with target genes and modulation of their expression. Elf-5′s ability to regulate gene expression in response to developmental cues underscores its significance in both normal physiology and disease states, making anti-Elf-5 antibody (G-2) an invaluable tool for researchers studying these critical processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Elf-5 Antibody (G-2) References:
- ELF5 isoform expression is tissue-specific and significantly altered in cancer. | Piggin, CL., et al. 2016. Breast Cancer Res. 18: 4. PMID: 26738740
- ELF5-Mediated AR Activation Regulates Prostate Cancer Progression. | Li, K., et al. 2017. Sci Rep. 7: 42759. PMID: 28287091
- ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer. | Luk, IY., et al. 2018. Molecules. 23: PMID: 30200227
- Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region. | Swahn, H., et al. 2019. J Cell Mol Med. 23: 7726-7740. PMID: 31557407
- Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. | Singh, S., et al. 2020. Nat Cell Biol. 22: 591-602. PMID: 32284542
- Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1. | Li, X., et al. 2021. NPJ Precis Oncol. 5: 20. PMID: 33742100
- Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation. | Miyano, M., et al. 2021. Cancer Prev Res (Phila). 14: 779-794. PMID: 34140348
- ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19. | Pietzner, M., et al. 2022. Nat Commun. 13: 4484. PMID: 35970849
- ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma. | Li, T., et al. 2023. Mol Cancer. 22: 184. PMID: 37980532
- ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility. | Miyano, M. and LaBarge, MA. 2024. Cancers (Basel). 16: PMID: 38275872
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Elf-5 Antibody (G-2) | sc-166653 | 200 µg/ml | $322.00 | |||
Elf-5 (G-2) Neutralizing Peptide | sc-166653 P | 100 µg/0.5 ml | $69.00 | |||
Elf-5 Antibody (G-2) X | sc-166653 X | 200 µg/0.1 ml | $322.00 |