Elf-5 Antibody (C-1): sc-376737

Elf-5 Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Elf-5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Elf-5 antibody (C-1) is available as the non-conjugated form. Elf-5, a member of the Ets transcription factor family, plays a crucial role in various biological processes, including the regulation of gene expression during development and differentiation. Elf-5 (C-1) antibody has proven particularly useful in studying lung, mammary, prostate, and kidney tissues, where Elf-5 influences cellular proliferation and differentiation. Elf-5 has been implicated in tumorigenesis, highlighting Elf-5′s potential as a biomarker for cancer progression. A highly conserved carboxy-terminal domain facilitates DNA binding, which is essential for transcriptional regulatory functions. This domain is shared among Ets family members, underscoring the evolutionary significance of the Ets gene family in cellular processes. Elf-5 (C-1) monoclonal antibody serves as a valuable tool for studying Elf-5′s role in health and disease.

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Elf-5 Antibody (C-1) References:

1. Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.  |  Donnison, M., et al. 2005. Development. 132: 2299-308. PMID: 15829518
2. Analysis of gene and protein expression during monocyte-macrophage differentiation and cholesterol loading--cDNA and protein array study.  |  Tuomisto, TT., et al. 2005. Atherosclerosis. 180: 283-91. PMID: 15910854
3. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins.  |  Burtis, KC., et al. 1990. Cell. 61: 85-99. PMID: 2107982
4. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.  |  Rao, VN., et al. 1989. Science. 244: 66-70. PMID: 2539641
5. Generation of Elf5-Cre knockin mouse strain for trophoblast-specific gene manipulation.  |  Kong, S., et al. 2018. Genesis. 56: e23101. PMID: 29532590
6. Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.  |  Ghysdael, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 1714-8. PMID: 3006066
7. Overexpression of E74-Like Factor 5 (ELF5) Inhibits Migration and Invasion of Ovarian Cancer Cells.  |  Zhang, X., et al. 2019. Med Sci Monit. 25: 856-865. PMID: 30696803
8. erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.  |  Rao, VN., et al. 1987. Science. 237: 635-9. PMID: 3299708
9. Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland.  |  Song, EAC., et al. 2023. J Dent Res. 102: 340-348. PMID: 36348499
10. The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.  |  Kola, I., et al. 1993. Proc Natl Acad Sci U S A. 90: 7588-92. PMID: 7689222
11. Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation.  |  Pongubala, JM., et al. 1993. Science. 259: 1622-5. PMID: 8456286
12. A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines.  |  Zhou, J., et al. 1998. Oncogene. 17: 2719-32. PMID: 9840936

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Elf-5 Antibody (C-1) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-Elf-5 Antibody (C-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Elf-5 Antibody (C-1) Specifications

Alternate Product Name: Elf-5

Product Clone Name: C-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 101-162

Epitope Target: Elf-5

Epitope Species: human

Product Reactivity/Detection: Elf-5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Elf-5 Antibody (C-1): X: TransCruz Reagent