elastin Antibody (A-8): sc-374638

Elastin Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects elastin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-elastin antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Elastin plays a crucial role in the extracellular matrix, primarily found in connective tissues, where elastin provides elasticity and resilience, allowing tissues to stretch and return to their original shape. This property is particularly important in structures that undergo frequent deformation, such as blood vessels, lungs, and skin. The unique structure of elastin, characterized by a high content of glycine, proline, and hydrophobic residues, enables elastin to form a rubber-like network through lysine-derived crosslinks, including desmosines. These crosslinks are vital for maintaining tissue elasticity; however, as individuals age, the cross-linking of collagen with elastin can lead to decreased tissue elasticity, contributing to age-related disorders. Furthermore, deficiencies in elastin are linked to various health conditions, including supravalvular aortic stenosis and Williams-Beuren syndrome, highlighting elastin′s significance in vascular health and development. The human elastin gene is located on chromosome 7q11.23, underscoring elastin′s genetic importance in the context of these disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-elastin Antibody (A-8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-elastin Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

elastin Antibody (A-8) Specifications

Alternate Product Name: elastin

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 371-407

Epitope Target: elastin

Epitope Species: human

Product Reactivity/Detection: precursor tropoelastin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for elastin Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred elastin antibody is elastin Antibody (BA-4): sc-58756.