Elastase-3A Antibody (14-3): sc-100527

Elastase-3A Antibody (14-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Elastase-3A protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Elastase-3A antibody (14-3) is available as a non-conjugated format. Elastase-3A, also known as ELA3A or ELA3, is a 270 amino acid protein that plays a crucial role in the digestive system as an alanine-specific protease. Secreted as a zymogen from the pancreas, Elastase-3A is activated in the intestine where Elastase-3A hydrolyzes a variety of proteins, particularly those rich in alanine residues, facilitating metabolic degradation. This enzymatic activity is vital for proper nutrient absorption and digestion, and Elastase-3A is also implicated in the metabolism and transport of cholesterol molecules within the intestinal environment. Notably, altered expression levels of Elastase-3A have been linked to pancreatic ductal carcinoma, a highly aggressive form of cancer affecting the pancreatic ducts, highlighting the importance of this protein in both digestive health and disease pathology.

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Elastase-3A Antibody (14-3) References:

1. Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.  |  Shimada, S., et al. 2002. Int J Mol Med. 10: 599-603. PMID: 12373299
2. Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.  |  Nemoda, Z. and Sahin-Tóth, M. 2006. J Biol Chem. 281: 11879-86. PMID: 16505482
3. Gene expression patterns in pancreatic tumors, cells and tissues.  |  Lowe, AW., et al. 2007. PLoS One. 2: e323. PMID: 17389914
4. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.  |  Shirasu, Y., et al. 1988. J Biochem. 104: 259-64. PMID: 2460440
5. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.  |  Tani, T., et al. 1988. J Biol Chem. 263: 1231-9. PMID: 2826474

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Elastase-3A Antibody (14-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Elastase-3A Antibody (14-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Elastase-3A Antibody (14-3) Specifications

Alternate Product Name: Elastase-3A

Product Clone Name: 14-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 16-271

Epitope Target: Elastase-3A

Epitope Species: human

Product Reactivity/Detection: Elastase-3A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Elastase-3A Antibody (14-3): N/A