eIF4E Antibody (D-3): sc-514875
- eIF4E Antibody (D-3) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 185-214 at the C-terminus of eIF4E of human origin
- recommended for detection of eIF4E of mouse, rat and human origin by WB, IP, IF and ELISA
- See eIF4E (P-2): sc-9976 for eIF4E antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG1 BP-HRP is the preferred secondary detection reagent for eIF4E Antibody (D-3) for WB applications. This reagent is now offered in a bundle with eIF4E Antibody (D-3) (see ordering information below).
eIF4E Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects eIF4E in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). eIF4E plays a crucial role in the regulation of protein synthesis by binding to the 5′ cap of mRNA, which is essential for the recruitment of the ribosome to the mRNA and the initiation of translation. This process is vital for cellular function and growth, as eIF4E ensures proteins are synthesized in response to cellular signals and environmental changes. eIF4E (D-3) antibody enables researchers to study processes such as cell proliferation and differentiation, where proper eIF4E function is particularly important. Dysregulation of eIF4E has been implicated in various diseases, including cancer. Anti-eIF4E antibody (D-3) helps researchers gain insights into the mechanisms of protein synthesis and its implications in health and disease, making eIF4E (D-3) monoclonal antibody an invaluable tool for studies in molecular biology and biochemistry.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
eIF4E Antibody (D-3) References:
- The mRNA cap-binding protein eIF4E in post-transcriptional gene expression. | von der Haar, T., et al. 2004. Nat Struct Mol Biol. 11: 503-11. PMID: 15164008
- eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. | Furic, L., et al. 2010. Proc Natl Acad Sci U S A. 107: 14134-9. PMID: 20679199
- eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. | Sundin, T., et al. 2013. Exp Cell Res. 319: 2103-2112. PMID: 23747720
- eIF4E-binding proteins: new factors, new locations, new roles. | Kamenska, A., et al. 2014. Biochem Soc Trans. 42: 1238-45. PMID: 25110031
- Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia. | Zhou, H., et al. 2020. Leuk Lymphoma. 61: 1084-1096. PMID: 29334312
- A novel eIF4E-interacting protein that forms non-canonical translation initiation complexes. | Toribio, R., et al. 2019. Nat Plants. 5: 1283-1296. PMID: 31819221
- eIF4E‑related miR‑320a and miR‑340‑5p inhibit endometrial carcinoma cell metastatic capability by preventing TGF‑β1‑induced epithelial‑mesenchymal transition. | Zhang, HH., et al. 2020. Oncol Rep. 43: 447-460. PMID: 31894279
- A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders. | Fischer, PD., et al. 2021. Eur J Med Chem. 219: 113435. PMID: 33892272
- PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation. | Wang, P., et al. 2024. Life Sci Alliance. 7: PMID: 39111820
- MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction. | Walker, NM., et al. 2024. J Clin Invest. 134: PMID: 39145446
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eIF4E Antibody (D-3) | sc-514875 | 200 µg/ml | $322.00 | |||
eIF4E Antibody (D-3): m-IgG1 BP-HRP Bundle | sc-542716 | 200 µg Ab; 20 µg BP | $361.00 | |||
eIF4E (D-3) Neutralizing Peptide | sc-514875 P | 100 µg/0.5 ml | $69.00 |