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eIF3η Antibody (D-9) - Western Blotting - Image 354820
eIF3η Antibody (D-9): sc-137215. Western blot analysis of eIF3η expression in HISM (A), HeLa (B), NIH/3T3 (C), RAW 264.7 (D), KNRK (E) and L8 (F) whole cell lysates.
eIF3η Antibody (D-9) - Western Blotting - Image 354820
eIF3η Antibody (D-9): sc-137215. Western blot analysis of eIF3η expression in HISM (A), HeLa (B), NIH/3T3 (C), RAW 264.7 (D), KNRK (E) and L8 (F) whole cell lysates.
eIF3η Antibody (D-9) - Western Blotting - Image 59597
eIF3η Antibody (D-9): sc-137215. Western blot analysis of eIF3η expression in non-transfected: sc-117752 (A) and mouse eIF3η transfected: sc-119982 (B) 293T whole cell lysates and A-431 (C) and Jurkat (D) nuclear extracts.
eIF3η Antibody (D-9): sc-137215. Western blot analysis of eIF3η expression in HISM (A), HeLa (B), NIH/3T3 (C), RAW 264.7 (D), KNRK (E) and L8 (F) whole cell lysates.

eIF3η Antibody (D-9): sc-137215

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Datasheets
  • eIF3η Antibody (D-9) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
  • raised against amino acids 131-300 mapping within an internal region of eIF3η of human origin
  • recommended for detection of eIF3η of mouse, rat and human origin by WB, IP, IF and ELISA
  • m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for eIF3η Antibody (D-9) for WB applications. These reagents are now offered in bundles with eIF3η Antibody (D-9) (see ordering information below).
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Additional eIF Antibodies including eIF1, eIF1AY, eIF2 α, eIF2B α, eIF2B β, eIF2B δ, eIF2B ε, eIF2 β, eIF2B γ, eIF2C, eIF2C2, eIF2C4, eIF2D, eIF3 p110, eIF3 α and eIF3 β

eIF3η Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects eIF3η in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). eIF3η is a crucial component of the eukaryotic initiation factor 3 complex, which plays a significant role in the regulation of protein synthesis by facilitating the assembly of the 40S ribosomal subunit. eIF3η is primarily located in the cytoplasm, where eIF3η interacts with other initiation factors and mRNA to form the pre-initiation complex necessary for translation. Proper localization of eIF3η is vital, as eIF3η ensures efficient protein synthesis, which is essential for cell growth and proliferation. Dysregulation of eIF3η has been implicated in various cancers, highlighting eIF3η′s importance in tumorigenesis and making eIF3η a potential target for therapeutic intervention. anti-eIF3η antibody (D-9) provides a reliable tool for researchers studying the mechanisms of translation initiation and its implications in disease.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

eIF3η Antibody (D-9) References:

  1. Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer.  |  Dong, Z. and Zhang, JT. 2006. Crit Rev Oncol Hematol. 59: 169-80. PMID: 16829125
  2. The role of eIF3 and its individual subunits in cancer.  |  Hershey, JW. 2015. Biochim Biophys Acta. 1849: 792-800. PMID: 25450521
  3. eIF3 controls cell size independently of S6K1-activity.  |  Schipany, K., et al. 2015. Oncotarget. 6: 24361-75. PMID: 26172298
  4. The function and clinical significance of eIF3 in cancer.  |  Yin, Y., et al. 2018. Gene. 673: 130-133. PMID: 29908282
  5. eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health.  |  Lin, Y., et al. 2020. Mol Cell. 79: 575-587.e7. PMID: 32589965
  6. Structure of a human 48S translational initiation complex.  |  Brito Querido, J., et al. 2020. Science. 369: 1220-1227. PMID: 32883864
  7. eIF3 interacts with histone H4 messenger RNA to regulate its translation.  |  Hayek, H., et al. 2021. J Biol Chem. 296: 100578. PMID: 33766559
  8. Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.  |  She, R., et al. 2023. Nucleic Acids Res. 51: 6355-6369. PMID: 37144468
  9. Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex.  |  Zhang, Q., et al. 2024. Cell Rep. 43: 113789. PMID: 38368608
  10. Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction.  |  Choi, JH., et al. 2024. Sci Adv. 10: eadl5638. PMID: 39018414

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

eIF3η Antibody (D-9)

sc-137215
200 µg/ml
$322.00

eIF3η Antibody (D-9): m-IgG Fc BP-HRP Bundle

sc-539961
200 µg Ab; 10 µg BP
$361.00

eIF3η Antibody (D-9): m-IgG1 BP-HRP Bundle

sc-541816
200 µg Ab; 20 µg BP
$361.00

I need to use an antibody to detect the protein in samples of avian origin. Do you know if sc-137215: eIF3η (D-9) mouse monoclonal antibody will work?

Asked by: DefinitelyNotMatt
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 4 out of 5 by from Good results observed by Western Blot using AGood results observed by Western Blot using A-431 and Jurkat nuclear extracts. -SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Good IF data with paraformaldehyde fixedGood IF data with paraformaldehyde fixed HeLa and U2OS cells. -SCBT Publication Review
Date published: 2015-04-05
Rated 4 out of 5 by from Robust signal obtained by Western Blot usingRobust signal obtained by Western Blot using whole cell lysates from 293T cells that have and have not been transfected to over-express the mouse eIF3 protein. -SCBT QC
Date published: 2013-07-06
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eIF3η Antibody (D-9) is rated 4.3 out of 5 by 3.
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