EHD2 Antibody (L-05): sc-100724

EHD2 Antibody (L-05) is a mouse monoclonal IgG1 antibody that detects EHD2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EHD2, also known as PAST2, is a 543 amino acid protein characterized by the presence of one EF-hand domain and one EH domain, which play crucial roles in its function. EHD2 is predominantly expressed in the heart, with lower expression levels found in the lung, placenta, and skeletal muscle. EHD2 is essential for the exit of receptors and other membrane proteins from the endosomal recycling compartment, a process vital for maintaining cellular homeostasis and regulating various signaling pathways. Notably, EHD2 interacts with the glucose transporter Glut4 and the endocytotic-associated protein EHBP1, facilitating the recruitment of Glut4 to the plasma membrane in response to insulin. This interaction is critical for glucose uptake and regulation of blood sugar levels, highlighting EHD2′s importance in metabolic processes. Furthermore, EHD2′s association with EHBP1 links endocytotic events to actin cytoskeleton dynamics, underscoring EHD2′s role in both glucose metabolism and cytoskeletal organization. With multifaceted functions and interactions, EHD2 is a key player in cellular processes that impact health and disease, making anti-EHD2 antibody (L-05) an invaluable tool for researchers studying these mechanisms.

The preferred EHD antibody is EHD Antibody (E-5): sc-271658.