Edc4 Antibody (H-12): sc-376382
- Edc4 Antibody (H-12) is a mouse monoclonal IgG3 κ Edc4 antibody, cited in 8 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 457-491 within an internal region of Edc4 of human origin
- recommended for detection of Edc4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Edc4 Antibody (H-12) for WB and IHC(P) applications. These reagents are now offered in bundles with Edc4 Antibody (H-12) (see ordering information below).
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Edc4 Antibody (H-12) is a mouse monoclonal IgG3 kappa light chain antibody that detects Edc4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Edc4 antibody (H-12) is available as non-conjugated format. Edc4, also known as enhancer of mRNA decapping 4, plays a pivotal role in regulating mRNA decay, a crucial process for maintaining cellular homeostasis and gene expression. Edc4 (H-12) antibody recognizes a protein involved in mRNA degradation′s decapping step, essential for mRNA molecule turnover and gene expression regulation in response to various cellular signals. Edc4 interacts with several key proteins, including hDcp1a and hDcp2a, forming a complex that facilitates decapping. Such interaction enables efficient mRNA removal, influencing mRNA stability and availability for translation. Edc4 localizes to processing bodies (P-bodies) and cytoplasm, with a nuclear localization sequence allowing nuclear entry, highlighting multiple roles in cellular processes. Post-translational modifications, such as phosphorylation in response to DNA damage, can affect Edc4 function and interactions. Located on human chromosome 16q22.1, Edc4 exists in two alternatively spliced isoforms, underscoring complexity and importance in mRNA metabolism.
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Edc4 Antibody (H-12) References:
- A protein interaction framework for human mRNA degradation. | Lehner, B. and Sanderson, CM. 2004. Genome Res. 14: 1315-23. PMID: 15231747
- Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. | Fenger-Grøn, M., et al. 2005. Mol Cell. 20: 905-15. PMID: 16364915
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | Beausoleil, SA., et al. 2006. Nat Biotechnol. 24: 1285-92. PMID: 16964243
- The immunoreactive region in a novel autoantigen contains a nuclear localization sequence. | Bloch, DB., et al. 1994. Clin Immunol Immunopathol. 72: 380-9. PMID: 7520377
- Cytoplasmic detection of a novel protein containing a nuclear localization sequence by human autoantibodies. | Garcia-Lozano, JR., et al. 1997. Clin Exp Immunol. 107: 501-6. PMID: 9067524
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Edc4 Antibody (H-12) | sc-376382 | 200 µg/ml | $322.00 | |||
Edc4 Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-529864 | 200 µg Ab; 10 µg BP | $361.00 | |||
Edc4 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-522937 | 200 µg Ab, 40 µg BP | $361.00 | |||
Edc4 (H-12) Neutralizing Peptide | sc-376382 P | 100 µg/0.5 ml | $69.00 |