ECM1 Antibody (G-7): sc-515843

ECM1 Antibody (G-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects ECM1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ECM1 antibody (G-7) is available in non-conjugated form. ECM1, or extracellular matrix protein 1, is a secreted glycoprotein that plays a crucial role in maintaining the structure and function of the skin. ECM1 is predominantly located in the extracellular matrix, where ECM1 interacts with various components such as Perlecan, Fibulin, and matrix metalloproteinase-9 (MMP-9), thereby contributing to the structural organization of the dermis. ECM1 enhances the association of Collagen Type IV with Laminin 332, highlighting ECM1′s importance in the integrity of the interstitial dermis and the dermal-epidermal junction. Mutations in the gene encoding ECM1 can lead to the autosomal recessive disorder lipoid proteinosis (LiP), which is characterized by dermal hyalinization and basement membrane reduplication, resulting in skin and mucosal thickening in affected individuals. ECM1 has four splice variants, known as ECM1a through ECM1d, which may have distinct functional roles.

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ECM1 Antibody (G-7) References:

1. Extracellular matrix 1 (ECM1) expression is a novel prognostic marker for poor long-term survival in breast cancer: a Hospital-based Cohort Study in Iowa.  |  Lal, G., et al. 2009. Ann Surg Oncol. 16: 2280-7. PMID: 19521735
2. Overexpression of ECM1 contributes to migration and invasion in cholangiocarcinoma cell.  |  Xiong, GP., et al. 2012. Neoplasma. 59: 409-15. PMID: 22489696
3. Human Melanoma cells over-express extracellular matrix 1 (ECM1) which is regulated by TFAP2C.  |  Lal, G., et al. 2013. PLoS One. 8: e73953. PMID: 24023917
4. Production and characterization of domain-specific monoclonal antibodies against human ECM1.  |  Li, Y., et al. 2016. Protein Expr Purif. 121: 103-11. PMID: 26826312
5. Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases.  |  Gómez-Contreras, P., et al. 2017. Clin Exp Metastasis. 34: 37-49. PMID: 27770373
6. HLA-A2.1-restricted ECM1-derived epitope LA through DC cross-activation priming CD8+ T and NK cells: a novel therapeutic tumour vaccine.  |  Yu, Z., et al. 2021. J Hematol Oncol. 14: 71. PMID: 33910591
7. Citri Reticulatae Pericarpium-Reynoutria japonica Houtt. herb pair suppresses breast cancer liver metastasis by targeting ECM1-mediated cholesterol biosynthesis pathway.  |  Wang, J., et al. 2023. Phytomedicine. 116: 154896. PMID: 37247588
8. ECM1-associated miR-1260b promotes osteogenic differentiation by targeting GDI1.  |  Li, J., et al. 2024. Acta Histochem. 126: 152133. PMID: 38266317
9. Extracellular matrix protein 1 (ECM1) is a potential biomarker in B cell acute lymphoblastic leukemia.  |  Wu, LX., et al. 2024. Clin Exp Med. 24: 56. PMID: 38546916
10. ECM1 and KRT6A are involved in tumor progression and chemoresistance in the effect of dexamethasone on pancreatic cancer.  |  Shinomiya, Y., et al. 2024. Cancer Sci. 115: 1948-1963. PMID: 38613239

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ECM1 Antibody (G-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ECM1 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ECM1 Antibody (G-7) Specifications

Alternate Product Name: ECM1

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 126-152

Epitope Target: ECM1

Epitope Species: human

Product Reactivity/Detection: ECM1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ECM1 Antibody (G-7): N/A

The preferred ECM1 antibody is ECM1 Antibody (C-12): sc-365946.