E6-AP Antibody (E-5): sc-166532

E6-AP Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects E6-AP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E6-AP, also known as ubiquitin protein ligase E3A (UBE3A), plays a crucial role in the ubiquitin-mediated proteolytic pathway, which maintains cellular homeostasis by selectively targeting proteins for degradation via the 26S proteasome. UBE3A antibody (E-5) recognizes a protein that conjugates ubiquitin to various substrates through enzymatic activity as an E3 ubiquitin ligase. E6-AP has been shown to interact with key proteins such as the tumor suppressor p53, forming a complex that enhances p53 ubiquitination, thereby regulating cellular levels. This interaction is particularly significant because accumulation of p53 due to impaired E6-AP activity can lead to severe consequences, including the development of Angelman syndrome, a neurodevelopmental disorder characterized by motor dysfunction and cognitive impairment. Anti-E6-AP antibody (E-5) serves as an invaluable tool for researchers studying protein degradation dynamics and E6-AP implications in various diseases, including cancer and genetic disorders.

The preferred E6-AP antibody is E6-AP Antibody (E-4): sc-166689.