E2F-5 Antibody (H-1): sc-271497
- E2F-5 Antibody (H-1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 89-200 of E2F-5 of human origin
- recommended for detection of E2F-5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine; non cross-reactive with E2F-6
- TransCruz reagent for ChIP application (sc-271497 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E2F-5 Antibody (H-1) for WB applications. These reagents are now offered in bundles with E2F-5 Antibody (H-1) (see ordering information below).
E2F-5 Antibody (H-1) is a mouse monoclonal IgG1 antibody that detects E2F-5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E2F-5 plays a crucial role in the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase, by forming heterodimers with the DP-1 protein to create an active E2F transcriptional regulatory complex. This complex is essential for the transcriptional activation of genes that are vital for DNA synthesis and cell proliferation. Dysregulation of E2F-5 can lead to uncontrolled cell growth and has been implicated in various cancers, making E2F-5 a significant target for therapeutic intervention. E2F-5′s interaction with other members of the E2F family, such as E2F-1, E2F-2, and E2F-3, further highlights E2F-5′s importance in maintaining proper cell cycle control and potential as a biomarker for tumor progression. Anti-E2F-5 antibody (H-1) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cancer development.
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E2F-5 Antibody (H-1) References:
- Active nuclear import and export pathways regulate E2F-5 subcellular localization. | Apostolova, MD., et al. 2002. J Biol Chem. 277: 34471-9. PMID: 12089160
- Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. | Ha, WY., et al. 2006. Int J Biochem Cell Biol. 38: 1393-401. PMID: 16546434
- Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice. | Chen, Q., et al. 2008. Mol Vis. 14: 602-14. PMID: 18385796
- Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. | Umemura, S., et al. 2009. Br J Cancer. 100: 764-71. PMID: 19259095
- E2F5 as an independent prognostic factor in esophageal squamous cell carcinoma. | Ishimoto, T., et al. 2013. Anticancer Res. 33: 5415-20. PMID: 24324077
- E2F-5, a new E2F family member that interacts with p130 in vivo. | Hijmans, EM., et al. 1995. Mol Cell Biol. 15: 3082-9. PMID: 7760804
- E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. | Sardet, C., et al. 1995. Proc Natl Acad Sci U S A. 92: 2403-7. PMID: 7892279
- Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. | Itoh, A., et al. 1995. Cell Mol Biol Res. 41: 147-54. PMID: 8589754
- The molecular and functional characterization of E2F-5 transcription factor. | Vaishnav, YN., et al. 1998. Biochem Biophys Res Commun. 242: 586-92. PMID: 9464260
- A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. | Lindeman, GJ., et al. 1998. Genes Dev. 12: 1092-8. PMID: 9553039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-5 Antibody (H-1) | sc-271497 | 200 µg/ml | $322.00 | |||
E2F-5 Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-537647 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2F-5 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-534980 | 200 µg Ab; 40 µg BP | $361.00 | |||
E2F-5 Antibody (H-1): m-IgG1 BP-HRP Bundle | sc-545281 | 200 µg Ab; 20 µg BP | $361.00 | |||
E2F-5 Antibody (H-1) X | sc-271497 X | 200 µg/0.1 ml | $322.00 |