E2F-2 Antibody (CC1): sc-69678
- E2F-2 Antibody (CC1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant E2F-2 of human origin
- recommended for detection of E2F-2 of human origin by WB and IP
- See E2F-2 (TFE-25): sc-9967 for E2F-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E2F-2 Antibody (CC1) for WB applications. These reagents are now offered in bundles with E2F-2 Antibody (CC1) (see ordering information below).
E2F-2 Antibody (CC1) is a mouse monoclonal IgG1 antibody that detects E2F-2 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. E2F-2 plays a crucial role in regulating the cell cycle, particularly in the transition from the G1 phase to the S phase, by controlling the expression of genes necessary for DNA synthesis and cell proliferation. This regulation is vital for maintaining proper cell growth and division, as dysregulation of E2F-2 can lead to uncontrolled cell proliferation and is often implicated in various cancers. E2F-2 functions as a transcription factor that forms heterodimers with the DP-1 protein, creating an active E2F transcriptional regulatory complex that binds to specific DNA sequences to activate target genes. The intricate balance of E2F-2 activity is essential for normal cellular function, and interactions with other proteins, such as the retinoblastoma protein (Rb), highlight E2F-2′s importance in the broader context of cell cycle regulation. Anti-E2F-2 antibody (CC1) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
E2F-2 Antibody (CC1) References:
- E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes. | Laresgoiti, U., et al. 2013. Nucleic Acids Res. 41: 10185-98. PMID: 24038359
- E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts. | Wang, S., et al. 2018. Arthritis Res Ther. 20: 225. PMID: 30286793
- Low E2F2 activity is associated with high genomic instability and PARPi resistance. | Rennhack, JP. and Andrechek, ER. 2020. Sci Rep. 10: 17948. PMID: 33087787
- E2F2 drives glioma progression via PI3K/AKT in a PFKFB4-dependent manner. | Zhang, L., et al. 2021. Life Sci. 276: 119412. PMID: 33774025
- E2F2 enhances the chemoresistance of pancreatic cancer to gemcitabine by regulating the cell cycle and upregulating the expression of RRM2. | Liu, Q., et al. 2022. Med Oncol. 39: 124. PMID: 35716217
- lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2. | Mao, W., et al. 2022. Open Med (Wars). 17: 1538-1549. PMID: 36245705
- Expression Profiles of CDKN2A, MDM2, E2F2 and LTF Genes in Oral Squamous Cell Carcinoma. | Gołąbek, K., et al. 2022. Biomedicines. 10: PMID: 36551770
- E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription. | Xiao, M., et al. 2023. Exp Clin Endocrinol Diabetes. 131: 162-172. PMID: 36893788
- miR-125b-5p, miR-155-3p, and miR-214-5p and Target E2F2 Gene in Oral Squamous Cell Carcinoma. | Gołąbek, K., et al. 2023. Int J Mol Sci. 24: PMID: 37047293
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-2 Antibody (CC1) | sc-69678 | 200 µg/ml | $322.00 | |||
E2F-2 Antibody (CC1): m-IgG Fc BP-HRP Bundle | sc-537187 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2F-2 Antibody (CC1): m-IgGκ BP-HRP Bundle | sc-534390 | 200 µg Ab; 40 µg BP | $361.00 | |||
E2F-2 Antibody (CC1): m-IgG1 BP-HRP Bundle | sc-545063 | 200 µg Ab; 20 µg BP | $361.00 |