E-Selectin/CD62E/SELE Antibody (1.2B6): sc-18852
- E-Selectin/CD62E/SELE Antibody (1.2B6) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against TNF-activated umbilical vein endothelial cells of human origin
- recommended for detection of E-Selectin of human and porcine origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See E-Selectin/CD62E/SELE (D-7): sc-137054 for E-Selectin/CD62E/SELE antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E-Selectin/CD62E/SELE Antibody (1.2B6) for WB applications. These reagents are now offered in bundles with E-Selectin/CD62E/SELE Antibody (1.2B6) (see ordering information below).
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E-Selectin Antibody (1.2B6) is a mouse monoclonal IgG1 antibody that detects E-Selectin in human and porcine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). E-Selectin, also known as ELAM-1 or CD62E, is a crucial adhesion molecule expressed on the surface of endothelial cells in response to pro-inflammatory cytokines. Anti-E-Selectin antibody (1.2B6) recognizes specific carbohydrates on leukocytes, facilitating the rolling and subsequent firm adhesion of these cells, thereby promoting their migration into tissues. This process is essential for effective immune surveillance and response, highlighting E-Selectin′s importance in both normal physiological processes and pathological conditions such as chronic inflammation and autoimmune diseases. E-Selectin monoclonal antibody (1.2B6) serves as an invaluable tool for researchers studying these critical cellular interactions and their implications in health and disease.
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E-Selectin/CD62E/SELE Antibody (1.2B6) References:
- E-selectin ligands as mechanosensitive receptors on neutrophils in health and disease. | Chase, SD., et al. 2012. Ann Biomed Eng. 40: 849-59. PMID: 22271244
- E-selectin ligand complexes adopt an extended high-affinity conformation. | Preston, RC., et al. 2016. J Mol Cell Biol. 8: 62-72. PMID: 26117840
- E-Selectin Mediates Immune Cell Trafficking in Corneal Transplantation. | Dohlman, TH., et al. 2016. Transplantation. 100: 772-80. PMID: 26910325
- E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases. | Morita, Y., et al. 2016. Mol Ther Nucleic Acids. 5: e399. PMID: 27959340
- New biomedical polymer targeting E-selectin to reduce atherosclerosis. | Park, K. 2018. J Control Release. 288: 277. PMID: 30290920
- Targeting E-selectin to Tackle Cancer Using Uproleselan. | Muz, B., et al. 2021. Cancers (Basel). 13: PMID: 33477563
- The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils. | Zhou, F., et al. 2021. J Cell Sci. 134: PMID: 34435628
- P- and E- selectin in venous thrombosis and non-venous pathologies. | Purdy, M., et al. 2022. J Thromb Haemost. 20: 1056-1066. PMID: 35243742
- The biology of E-selectin ligands in leukemogenesis. | Ales, E. and Sackstein, R. 2023. Adv Cancer Res. 157: 229-250. PMID: 36725110
- Selectins in Biology and Human Disease: Opportunity in E-selectin Antagonism. | Peterson, JM., et al. 2024. Cureus. 16: e61996. PMID: 38983984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-Selectin/CD62E/SELE Antibody (1.2B6) | sc-18852 | 200 µg/ml | $322.00 | |||
E-Selectin/CD62E/SELE Antibody (1.2B6): m-IgG Fc BP-HRP Bundle | sc-536600 | 200 µg Ab; 10 µg BP | $361.00 | |||
E-Selectin/CD62E/SELE Antibody (1.2B6): m-IgGκ BP-HRP Bundle | sc-533755 | 200 µg Ab; 40 µg BP | $361.00 | |||
E-Selectin/CD62E/SELE Antibody (1.2B6) FITC | sc-18852 FITC | 200 µg/ml | $336.00 | |||
E-Selectin/CD62E/SELE Antibody (1.2B6) L | sc-18852 L | 200 µg/0.1 ml | $322.00 | |||
E-Selectin/CD62E/SELE Antibody (1.2B6) PE | sc-18852 PE | 200 µg/ml | $349.00 |