E-FABP Antibody (A-9): sc-365236

E-FABP Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects E-FABP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-E-FABP antibody (A-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. E-FABP, also known as epidermal-type fatty acid-binding protein, is a member of the fatty acid-binding protein family, which consists of cytoplasmic proteins crucial for lipid and carbohydrate metabolism. These proteins facilitate uptake, transport, and targeting of fatty acids and hydrophobic ligands within specific tissues, employing mechanisms that include both passive diffusion and protein-mediated transmembrane transport. E-FABP is predominantly expressed in the epidermis and plays a significant role in keratinocyte differentiation, binding to stearic acid and influencing cellular processes. Notably, E-FABP is upregulated in rat dorsal root ganglia following sciatic nerve injury and during neuronal differentiation, highlighting its importance in both developmental and regenerative contexts. The ability of E-FABP to interact with various signaling pathways underscores its potential as a therapeutic target in conditions related to lipid metabolism and nerve regeneration.

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E-FABP Antibody (A-9) References:

1. Depletion of a fatty acid-binding protein impairs neurite outgrowth in PC12 cells.  |  Allen, GW., et al. 2000. Brain Res Mol Brain Res. 76: 315-24. PMID: 10762707
2. The fatty acid transport function of fatty acid-binding proteins.  |  Storch, J. and Thumser, AE. 2000. Biochim Biophys Acta. 1486: 28-44. PMID: 10856711
3. Unravelling the significance of cellular fatty acid-binding proteins.  |  Glatz, JF. and Storch, J. 2001. Curr Opin Lipidol. 12: 267-74. PMID: 11353329
4. Fatty acid-binding proteins of nervous tissue.  |  Veerkamp, JH. and Zimmerman, AW. 2001. J Mol Neurosci. 16: 133-42; discussion 151-7. PMID: 11478368
5. Analysis on the phenotype of E-FABP-gene knockout mice.  |  Owada, Y., et al. 2002. Mol Cell Biochem. 239: 83-6. PMID: 12479572
6. The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP.  |  Münz, M., et al. 2005. Cancer Lett. 225: 151-7. PMID: 15922867
7. TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP.  |  Knöferle, J., et al. 2010. Neurobiol Dis. 38: 395-404. PMID: 20211260
8. Effect of methotrexate treatment on the expression of epidermal-fatty acid-binding protein (E-FABP) and apolipoproteins in patients with psoriasis.  |  Owczarczyk-Saczonek, A., et al. 2020. Postepy Dermatol Alergol. 37: 401-406. PMID: 32792883
9. Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP-Mediated Mitochondrial Dysfunction.  |  Jin, R., et al. 2021. Cancer Res. 81: 5296-5310. PMID: 34400394
10. Cytoplasmic fatty acid-binding proteins: their structure and genes.  |  Veerkamp, JH. and Maatman, RG. 1995. Prog Lipid Res. 34: 17-52. PMID: 7644552
11. Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP).  |  Siegenthaler, G., et al. 1993. Biochem Biophys Res Commun. 190: 482-7. PMID: 8427590
12. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.  |  Hotamisligil, GS., et al. 1996. Science. 274: 1377-9. PMID: 8910278

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-E-FABP Antibody (A-9) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-E-FABP Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

E-FABP Antibody (A-9) Specifications

Alternate Product Name: FABP5

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 29-73

Epitope Target: E-FABP

Epitope Species: human

Product Reactivity/Detection: E-FABP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for E-FABP Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin