E-cadherin Antibody (6F9): sc-52328

E-cadherin Antibody (6F9) is a mouse monoclonal IgG1 antibody that detects E-cadherin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). E-cadherin plays a crucial role in maintaining epithelial integrity and tissue architecture by facilitating cell-cell adhesion, which is essential for proper morphogenesis and the prevention of tumor metastasis. E-cadherin is primarily located at the cell membrane, where E-cadherin forms adherens junctions with neighboring cells, thereby contributing to the formation of tight epithelial layers. E-cadherin′s location at the membrane is critical, as dysfunction or loss is often associated with increased cellular motility and invasiveness, hallmark features of cancer progression. E-cadherin′s extracellular domain is characterized by a series of five homologous repeats that are vital for adhesive properties, while E-cadherin′s intracellular domain interacts with cytoplasmic proteins like β-catenin, linking to the actin cytoskeleton and influencing cellular signaling pathways. Anti-E-cadherin antibody (6F9) is an invaluable tool for researchers studying cell adhesion mechanisms, epithelial biology, and cancer metastasis.

The preferred E-cadherin antibody is E-cadherin Antibody (G-10): sc-8426.