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E-cadherin Antibody (5H9) is a mouse monoclonal IgG1 antibody that detects E-cadherin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. E-cadherin plays a crucial role in maintaining cell-cell adhesion, which is essential for the integrity of epithelial tissues and the regulation of morphogenetic processes. E-cadherin is primarily located at the cell membrane, where adherens junctions form to connect adjacent cells, thereby contributing to tissue architecture and stability. E-cadherin′s function is vital for preventing tumor metastasis, as loss of expression often associates with increased invasiveness of cancer cells. E-cadherin′s extracellular domain interacts with other cadherins and cytoplasmic proteins, such as β-catenin, which are involved in signaling pathways that regulate cell proliferation and differentiation. Anti-E-cadherin antibody (5H9) enables researchers to gain insights into cell adhesion mechanisms and E-cadherin′s implications in various diseases, particularly in cancer research.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-cadherin Antibody (5H9) | sc-52327 | 50 µg/0.5 ml | $316.00 |