E-cadherin Antibody (2Q663): sc-71008
- E-cadherin Antibody (2Q663) is a mouse monoclonal IgG1 κ, cited in 57 publications, provided at 200 µg/ml
- raised against human breast carcinoma cell line T471
- recommended for detection of E-cadherin of human origin by WB, IP, IF and FCM
- See E-cadherin (G-10): sc-8426 for E-cadherin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for E-cadherin Antibody (2Q663) for WB applications. These reagents are now offered in bundles with E-cadherin Antibody (2Q663) (see ordering information below).
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E-cadherin Antibody (2Q663) is a mouse monoclonal IgG1 antibody that detects E-cadherin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). E-cadherin plays a crucial role in maintaining epithelial tissue integrity by mediating cell-cell adhesion, which is essential for proper tissue architecture and function. E-cadherin (2Q663) antibody targets proteins primarily located at the cell membrane, where adherens junctions form to connect adjacent cells, thereby preventing cancer cell invasion and maintaining structural stability of tissues. The extracellular domain of E-cadherin is composed of five homologous repeats that facilitate homophilic binding between neighboring cells, while its intracellular domain interacts with cytoplasmic proteins like β-catenin, linking E-cadherin to the actin cytoskeleton and influencing cellular signaling pathways. The importance of E-cadherin in tumor suppression highlights its potential as a biomarker for cancer progression, making anti-E-cadherin antibody (2Q663) an invaluable tool for researchers studying cell adhesion mechanisms and their implications in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-cadherin Antibody (2Q663) | sc-71008 | 200 µg/ml | $322.00 | |||
E-cadherin Antibody (2Q663): m-IgG Fc BP-HRP Bundle | sc-539328 | 200 µg Ab; 10 µg BP | $361.00 | |||
E-cadherin Antibody (2Q663): m-IgG1 BP-HRP Bundle | sc-541412 | 200 µg Ab; 20 µg BP | $361.00 |