Dysbindin Antibody (D-8): sc-390626
- Dysbindin Antibody (D-8) is a mouse monoclonal IgG1 κ Dysbindin antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 233-262 near the C-terminus of Dysbindin isoforms 1 and 2 of human origin
- Dysbindin Antibody (D-8) is recommended for detection of Dysbindin isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Dysbindin Antibody (D-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dysbindin Antibody (D-8) for WB and IHC(P) applications. These reagents are now offered in bundles with Dysbindin Antibody (D-8) (see ordering information below).
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Dysbindin Antibody (D-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dysbindin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Dysbindin antibody (D-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dysbindin plays a crucial role in the biogenesis of lysosome-related organelles, which is essential for proper functioning of various cellular processes, including protein trafficking and maintenance of cellular homeostasis. Dysbindin is particularly significant in Hermansky-Pudlak syndrome (HPS), a rare genetic disorder characterized by oculocutaneous albinism, lysosomal storage defects, and prolonged bleeding due to platelet storage pool deficiency. Dysbindin is involved in forming three distinct protein complexes vital for development and function of melanosomes, platelet dense granules, and lysosomes. Dysbindin interacts with dystrobrevins within the dystrophin-associated protein complex, highlighting its importance in cellular signaling and structural integrity. Additionally, Dysbindin exists in multiple isoforms due to alternative splicing, which may contribute to diverse functional roles in different tissues.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dysbindin Antibody (D-8) References:
- The dysbindin gene in major depression: an association study. | Zill, P., et al. 2004. Am J Med Genet B Neuropsychiatr Genet. 129B: 55-8. PMID: 15274041
- Schizophrenia genetics: dysbindin under the microscope. | Benson, MA., et al. 2004. Trends Neurosci. 27: 516-9. PMID: 15331232
- Schizophrenia genetics and dysbindin: a corner turned? | Kendler, KS. 2004. Am J Psychiatry. 161: 1533-6. PMID: 15337639
- Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. | Numakawa, T., et al. 2004. Hum Mol Genet. 13: 2699-708. PMID: 15345706
- Neurodevelopment, neuroplasticity, and new genes for schizophrenia. | Arnold, SE., et al. 2005. Prog Brain Res. 147: 319-45. PMID: 15581715
- [In search of susceptibility genes for schizophrenia]. | Schosser, A. and Aschauer, HN. 2004. Wien Klin Wochenschr. 116: 827-33. PMID: 15690966
- Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). | Raybould, R., et al. 2005. Biol Psychiatry. 57: 696-701. PMID: 15820225
- Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. | Bray, NJ., et al. 2005. Hum Mol Genet. 14: 1947-54. PMID: 15917270
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dysbindin Antibody (D-8) | sc-390626 | 200 µg/ml | $322.00 | |||
Dysbindin Antibody (D-8): m-IgG Fc BP-HRP Bundle | sc-530205 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dysbindin Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-523608 | 200 µg Ab, 40 µg BP | $361.00 | |||
Dysbindin Antibody (D-8): m-IgG1 BP-HRP Bundle | sc-543928 | 200 µg Ab; 20 µg BP | $361.00 | |||
Dysbindin Antibody (D-8) AC | sc-390626 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Dysbindin Antibody (D-8) HRP | sc-390626 HRP | 200 µg/ml | $322.00 | |||
Dysbindin Antibody (D-8) FITC | sc-390626 FITC | 200 µg/ml | $336.00 | |||
Dysbindin Antibody (D-8) PE | sc-390626 PE | 200 µg/ml | $349.00 | |||
Dysbindin Antibody (D-8) Alexa Fluor® 488 | sc-390626 AF488 | 200 µg/ml | $364.00 | |||
Dysbindin Antibody (D-8) Alexa Fluor® 546 | sc-390626 AF546 | 200 µg/ml | $364.00 | |||
Dysbindin Antibody (D-8) Alexa Fluor® 594 | sc-390626 AF594 | 200 µg/ml | $364.00 | |||
Dysbindin Antibody (D-8) Alexa Fluor® 647 | sc-390626 AF647 | 200 µg/ml | $364.00 | |||
Dysbindin Antibody (D-8) Alexa Fluor® 680 | sc-390626 AF680 | 200 µg/ml | $364.00 | |||
Dysbindin Antibody (D-8) Alexa Fluor® 790 | sc-390626 AF790 | 200 µg/ml | $364.00 | |||
Dysbindin (D-8) Neutralizing Peptide | sc-390626 P | 100 µg/0.5 ml | $69.00 |