Dyrk1B Antibody (H-6): sc-390417
- Dyrk1B Antibody (H-6) is a mouse monoclonal IgG1 κ Dyrk1B antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 501-539 within an internal region of Dyrk1B of human origin
- Dyrk1B Antibody (H-6) is recommended for detection of Dyrk1B of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and bovine
- Anti-Dyrk1B Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dyrk1B Antibody (H-6) for WB applications. These reagents are now offered in bundles with Dyrk1B Antibody (H-6) (see ordering information below).
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Dyrk1B Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dyrk1B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dyrk1B (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dyrk1B, a member of the dual specificity tyrosine phosphorylation regulated kinase family, plays a pivotal role in cellular processes such as muscle differentiation and neurogenesis. Dyrk1B localizes to the nucleus and is essential for regulating motility, transcription, cell cycle progression, and cell survival, particularly in muscle and testis tissues. Dyrk1B is implicated in several solid tumors, functioning as a downstream effector of Rac1 or K-ras to promote cell survival. Dyrk1B′s dual-specificity kinase activity allows phosphorylation of both tyrosine and serine/threonine residues, which is crucial for regulatory functions in cellular growth and development. Anti-Dyrk1B antibody (H-6) enables researchers to explore Dyrk1B′s intricate roles in various biological contexts, enhancing understanding of its contributions to health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dyrk1B Antibody (H-6) References:
- The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling. | Jin, K., et al. 2005. J Biol Chem. 280: 42097-105. PMID: 16257974
- Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival. | Mercer, SE. and Friedman, E. 2006. Cell Biochem Biophys. 45: 303-15. PMID: 16845176
- The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer. | Jin, K., et al. 2007. Cancer Res. 67: 7247-55. PMID: 17671193
- Mirk regulates the exit of colon cancer cells from quiescence. | Jin, K., et al. 2009. J Biol Chem. 284: 22916-25. PMID: 19542220
- Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. | Becker, W., et al. 1998. J Biol Chem. 273: 25893-902. PMID: 9748265
- Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. | Leder, S., et al. 1999. Biochem Biophys Res Commun. 254: 474-9. PMID: 9918863
- Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. | Becker, W. and Joost, HG. 1999. Prog Nucleic Acid Res Mol Biol. 62: 1-17. PMID: 9932450
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dyrk1B Antibody (H-6) | sc-390417 | 200 µg/ml | $316.00 | |||
Dyrk1B Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-530152 | 200 µg Ab; 10 µg BP | $354.00 | |||
Dyrk1B Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-523528 | 200 µg Ab, 40 µg BP | $354.00 | |||
Dyrk1B Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-543895 | 200 µg Ab; 20 µg BP | $354.00 | |||
Dyrk1B Antibody (H-6) AC | sc-390417 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Dyrk1B Antibody (H-6) HRP | sc-390417 HRP | 200 µg/ml | $316.00 | |||
Dyrk1B Antibody (H-6) FITC | sc-390417 FITC | 200 µg/ml | $330.00 | |||
Dyrk1B Antibody (H-6) PE | sc-390417 PE | 200 µg/ml | $343.00 | |||
Dyrk1B Antibody (H-6) Alexa Fluor® 488 | sc-390417 AF488 | 200 µg/ml | $357.00 | |||
Dyrk1B Antibody (H-6) Alexa Fluor® 546 | sc-390417 AF546 | 200 µg/ml | $357.00 | |||
Dyrk1B Antibody (H-6) Alexa Fluor® 594 | sc-390417 AF594 | 200 µg/ml | $357.00 | |||
Dyrk1B Antibody (H-6) Alexa Fluor® 647 | sc-390417 AF647 | 200 µg/ml | $357.00 | |||
Dyrk1B Antibody (H-6) Alexa Fluor® 680 | sc-390417 AF680 | 200 µg/ml | $357.00 | |||
Dyrk1B Antibody (H-6) Alexa Fluor® 790 | sc-390417 AF790 | 200 µg/ml | $357.00 | |||
Dyrk1B (H-6) Neutralizing Peptide | sc-390417 P | 100 µg/0.5 ml | $68.00 |