Dynein IC1/2, cytosolic Antibody (2Q46): sc-70997

Dynein IC1/2, cytosolic Antibody (2Q46) is a mouse monoclonal IgG2b antibody that detects Dynein across a broad range of species by applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-Dynein IC1/2 antibody (2Q46) targets the cytoplasmic Dynein complex, which is essential for various cellular processes, including organelle transport and centrosome assembly. This complex is composed of approximately 12 subunits, featuring two heavy chains that are crucial for motor function, two intermediate chains that anchor Dynein to its cargo, and several light chains that contribute to stability and regulation. The heavy chains of Dynein contain motor domains that convert ATP hydrolysis into mechanical work, allowing the transport of cellular components toward the minus end of microtubules. The carboxy terminus of Dynein is highly conserved and plays a vital role in microtubule-dependent motility, while the more variable amino terminal regions may influence the interaction with specific cargoes. Additionally, Dynein′s activity is regulated by several proteins, including dynactin, LIS1, and NudEL (NudE-like), which are critical for function in cellular dynamics. The ability of Dynein to facilitate the movement of organelles and other cellular structures underscores importance in maintaining cellular organization and function, making Dynein IC1/2 (2Q46) monoclonal antibody a valuable tool for researchers studying these processes.

The preferred Dynein IC1/2, cytosolic antibody is Dynein IC1/2, cytosolic Antibody (74-1): sc-13524.