Dynactin 6 Antibody (B-6): sc-398694

Dynactin 6 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dynactin 6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Dynactin 6 antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dynactin 6, also known as Protein WS-3, plays a crucial role in the cellular transport system by serving as a key component of the pointed-end-binding subcomplex of the Dynactin complex, which is essential for the proper functioning of the Dynein motor protein. This complex is vital for the movement of cellular cargo along microtubules, facilitating processes such as organelle transport, mitosis, and the maintenance of cellular architecture. The interaction between Dynactin 6 and other subunits, such as Dynactin 5 and Dynactin p62, is critical for regulating the binding of Dynactin to membranous cargo, thereby influencing the efficiency and specificity of intracellular transport. Dynactin 6 is ubiquitously expressed across various tissues, making this protein indispensable for the overall health and functionality of all organs, highlighting its importance in cellular dynamics and transport mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Dynactin 6 Antibody (B-6) References:

1. Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end.  |  Eckley, DM., et al. 1999. J Cell Biol. 147: 307-20. PMID: 10525537
2. Null mutants of the neurospora actin-related protein 1 pointed-end complex show distinct phenotypes.  |  Lee, IH., et al. 2001. Mol Biol Cell. 12: 2195-206. PMID: 11452013
3. Three-dimensional reconstruction of the dynactin complex by single-particle image analysis.  |  Hodgkinson, JL., et al. 2005. Proc Natl Acad Sci U S A. 102: 3667-72. PMID: 15738427
4. Cytoplasmic dynein/dynactin function and dysfunction in motor neurons.  |  Levy, JR. and Holzbaur, EL. 2006. Int J Dev Neurosci. 24: 103-11. PMID: 16406469
5. Dynactin function in mitotic spindle positioning.  |  Moore, JK., et al. 2008. Traffic. 9: 510-27. PMID: 18221362
6. Regulation of dynactin through the differential expression of p150Glued isoforms.  |  Dixit, R., et al. 2008. J Biol Chem. 283: 33611-9. PMID: 18812314
7. Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam.  |  Yang, JS., et al. 2008. PLoS One. 3: e3504. PMID: 18946501
8. Cloning and characterization of a novel gene, WS-3, in human chromosome 8p11-p12.  |  Ichikawa, K., et al. 1997. Gene. 189: 277-87. PMID: 9168138

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dynactin 6 Antibody (B-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Dynactin 6 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dynactin 6 Antibody (B-6) Specifications

Alternate Product Name: Dynactin 6

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 18-46

Epitope Target: Dynactin 6

Epitope Species: human

Product Reactivity/Detection: Dynactin 6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Dynactin 6 Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin