Dvl-3/Dishevelled 3/DVL3 Antibody (C-3): sc-365581

Dvl-3 Antibody (C-3) is a mouse monoclonal IgM antibody that detects Dvl-3 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Dvl-3 (C-3) monoclonal antibody specifically recognizes an epitope mapping between amino acids 73-101 near the N-terminus of Dvl-3 of human origin. Anti-Dvl-3 antibody (C-3), a member of the dishevelled protein family, plays a crucial role in the Wnt signaling pathway, which regulates cell proliferation, differentiation, and embryonic development. Dvl-3 (C-3) monoclonal antibody targets proteins primarily located in the cytoplasm that can translocate to the plasma membrane upon Wnt signaling activation, highlighting importance in cellular communication and signaling cascades. Disruption of Dvl-3 function has been implicated in various developmental disorders and cancers, making Dvl-3 a significant target for research in understanding these diseases. Dvl-3 interacts with several key proteins, including frizzled receptors and axin, which are vital for proper functioning of the Wnt pathway. These interactions underscore Dvl-3′s importance in maintaining cellular homeostasis and potential as a therapeutic target in Wnt-related pathologies.

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Dvl-3/Dishevelled 3/DVL3 Antibody (C-3) References:

1. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.  |  Kishida, S., et al. 1999. Mol Cell Biol. 19: 4414-22. PMID: 10330181
2. The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3.  |  Sutton, LP. and Rushlow, WJ. 2012. Int J Neuropsychopharmacol. 15: 965-79. PMID: 21777508
3. Dishevelled-3 activates p65 to upregulate p120-catenin transcription via a p38-dependent pathway in non-small cell lung cancer.  |  Zhao, H., et al. 2015. Mol Carcinog. 54 Suppl 1: E112-21. PMID: 25156800
4. Synergistic effect of targeting dishevelled-3 and the epidermal growth factor receptor-tyrosine kinase inhibitor on mesothelioma cells in vitro.  |  Moriyama, G., et al. 2018. Oncol Lett. 15: 833-838. PMID: 29403559
5. Omega-3 polyunsaturated fatty acid inhibits the malignant progression of hepatocarcinoma by inhibiting the Wnt/β-catenin pathway.  |  Chang, FZ., et al. 2018. Eur Rev Med Pharmacol Sci. 22: 4500-4508. PMID: 30058686
6. ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-β-catenin signaling.  |  Pai, VC., et al. 2019. Oncogene. 38: 1340-1353. PMID: 30266990
7. Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain.  |  Pan, B. and Deng, C. 2019. Psychopharmacology (Berl). 236: 2687-2697. PMID: 31053935
8. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.  |  Pizzuti, A., et al. 1996. Hum Mol Genet. 5: 953-8. PMID: 8817329
9. cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.  |  Bui, TD., et al. 1997. Biochem Biophys Res Commun. 239: 510-6. PMID: 9344861

The preferred Dvl-3/Dishevelled 3/DVL3 antibody is Dvl-3/Dishevelled 3/DVL3 Antibody (4D3): sc-8027.