Dvl-2/Dishevelled 2/DVL2 Antibody (10B5): sc-8026

Dvl-2 Antibody (10B5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dvl-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Dvl-2 antibody (10B5) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Dvl-2 plays a crucial role in the Wnt signaling pathway, which regulates cell proliferation, differentiation, and embryonic development. This pathway is particularly important in cancer research, as aberrations in Wnt signaling can lead to tumorigenesis. Dvl-2, along with homologs Dvl-1 and Dvl-3, contains three homologous domains, two unique to the dishevelled family, while the third resembles the discs-large homology domain found in the Drosophila tumor suppressor protein. The structural characteristics of Dvl-2 are vital for mediating cellular responses to Wnt signals, and understanding these interactions can provide insights into developmental processes and disease mechanisms.

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Dvl-2/Dishevelled 2/DVL2 Antibody (10B5) References:

1. Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.  |  Smalley, MJ., et al. 1999. EMBO J. 18: 2823-35. PMID: 10329628
2. Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta.  |  Smalley, MJ., et al. 2005. J Cell Sci. 118: 5279-89. PMID: 16263761
3. Non-canonical Wnt induces chondrocyte de-differentiation through Frizzled 6 and DVL-2/B-raf/CaMKIIα/syndecan 4 axis.  |  Xie, Z., et al. 2018. Cell Death Differ. 25: 1442-1456. PMID: 29352270
4. MiR-495 targeting dvl-2 represses the inflammatory response of ankylosing spondylitis.  |  Du, W., et al. 2019. Am J Transl Res. 11: 2742-2753. PMID: 31217850
5. Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.  |  Sussman, DJ., et al. 1994. Dev Biol. 166: 73-86. PMID: 7958461
6. Dishevelled is a component of the frizzled signaling pathway in Drosophila.  |  Krasnow, RE., et al. 1995. Development. 121: 4095-102. PMID: 8575310
7. Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.  |  Pizzuti, A., et al. 1996. Am J Hum Genet. 58: 722-9. PMID: 8644734
8. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.  |  Pizzuti, A., et al. 1996. Hum Mol Genet. 5: 953-8. PMID: 8817329
9. Isolation and characterization of mouse dishevelled-3.  |  Tsang, M., et al. 1996. Dev Dyn. 207: 253-62. PMID: 8922524
10. A frizzled homolog functions in a vertebrate Wnt signaling pathway.  |  Yang-Snyder, J., et al. 1996. Curr Biol. 6: 1302-6. PMID: 8939578
11. Human dishevelled genes constitute a DHR-containing multigene family.  |  Semënov, MV. and Snyder, M. 1997. Genomics. 42: 302-10. PMID: 9192851
12. Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.  |  Wagner, U., et al. 1997. FEBS Lett. 411: 369-72. PMID: 9271238

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dvl-2/Dishevelled 2/DVL2 Antibody (10B5) has 60 citations in a variety of scientific publications.

Primary antibodies like Anti-Dvl-2/Dishevelled 2/DVL2 Antibody (10B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dvl-2/Dishevelled 2/DVL2 Antibody (10B5) Specifications

Alternate Product Name: Dvl-2

Product Clone Name: 10B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 594-736

Epitope Target: Dvl-2

Epitope Species: mouse

Product Reactivity/Detection: Dvl-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 60 citations in various scientific publications

Available Conjugates/Forms for Dvl-2/Dishevelled 2/DVL2 Antibody (10B5): AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790