Date published: 2026-5-3

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Dvl-2 Inhibitors

Dvl-2 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Disheveled-2 (Dvl-2). Dvl-2 is a crucial component of the Wnt signaling pathway, a highly conserved cellular pathway that plays essential roles in embryonic development, tissue homeostasis, and cellular processes such as proliferation, differentiation, and migration. Dvl-2 acts as a cytoplasmic protein that transduces signals from cell surface Wnt receptors to intracellular components, leading to the activation of downstream signaling cascades. Dvl-2 inhibitors work by specifically targeting the Dvl-2 protein, disrupting its interactions with other components of the Wnt pathway and interfering with its role in signal transmission. By doing so, these inhibitors may modulate the transduction of Wnt signals and influence various cellular responses that are regulated by the Wnt pathway. Research into Dvl-2 inhibitors is ongoing to uncover their precise mechanisms of action and explore their implications in understanding cellular signaling pathways. The study of Dvl-2 inhibitors contributes to a deeper comprehension of the intricate mechanisms underlying developmental processes and cellular behaviors governed by the Wnt signaling pathway.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Pyrvinium Pamoate

3546-41-6sc-476920A
sc-476920
250 mg
500 mg
$228.00
$422.00
(0)

Downregulates Dvl-2 levels, potentially inhibiting Wnt signaling and reducing cell proliferation in colorectal cancer cells and other Wnt-dependent malignancies.

KY02111

1118807-13-8sc-397043
sc-397043A
5 mg
25 mg
$79.00
$336.00
(0)

Antagonizes Dvl-2 by inhibiting its interaction with Axin, disrupting the formation of the destruction complex and potentially modulating Wnt signaling and cell fate determination.

β-Catenin/Tcf Inhibitor, FH535

108409-83-2sc-221398
sc-221398A
10 mg
50 mg
$182.00
$374.00
7
(1)

Inhibits Dvl-2 and its downstream β-catenin/Tcf interaction, disrupting the canonical Wnt pathway and potentially attenuating cell proliferation and tumorigenesis.

IWR-1-endo

1127442-82-3sc-295215
sc-295215A
5 mg
10 mg
$82.00
$135.00
19
(1)

Antagonizes Dvl-2 by promoting its interaction with Axin, leading to degradation of Dvl-2 and inhibition of the canonical Wnt pathway and its associated cellular processes.

XAV939

284028-89-3sc-296704
sc-296704A
sc-296704B
1 mg
5 mg
50 mg
$36.00
$117.00
$525.00
26
(1)

Targets tankyrase, inhibiting poly-ADP-ribosylation of Axin and leading to its stabilization, which in turn inhibits Dvl-2 activity and the canonical Wnt signaling pathway.